- 2-Mercaptobenzoxazole
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- $119.00
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2026-05-29
- CAS:2382-96-9
- Min. Order: 1kg
- Purity: 0.98
- Supply Ability: 100kg
- 2-Mercaptobenzoxazole
-
-
2026-05-29
- CAS:2382-96-9
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 30tons/month
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| | 2-Mercaptobenzoxazole Basic information |
| | 2-Mercaptobenzoxazole Chemical Properties |
| Melting point | 192-195 °C(lit.) | | Boiling point | 360°C (rough estimate) | | density | 1.2170 (rough estimate) | | refractive index | 1.5500 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | form | Crystalline Powder | | pka | 11.03±0.20(Predicted) | | color | Beige | | PH | 5 (5g/l, H2O, 20℃) | | Water Solubility | SLIGHTLY SOLUBLE | | BRN | 119483 | | InChI | 1S/C7H5NOS/c10-7-8-5-3-1-2-4-6(5)9-7/h1-4H,(H,8,10) | | InChIKey | FLFWJIBUZQARMD-UHFFFAOYSA-N | | SMILES | Sc1nc2ccccc2o1 | | CAS DataBase Reference | 2382-96-9(CAS DataBase Reference) | | NIST Chemistry Reference | 2(3H)-Benzoxazolethione(2382-96-9) | | EPA Substance Registry System | 2-Mercaptobenzoxazole (2382-96-9) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 22-24/25-25-24-36-26 | | WGK Germany | 3 | | RTECS | DM4882500 | | F | 13 | | TSCA | TSCA listed | | HS Code | 29349990 | | Storage Class | 11 - Combustible Solids | | Toxicity | mouse,LD50,intravenous,180mg/kg (180mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04482, |
| | 2-Mercaptobenzoxazole Usage And Synthesis |
| Chemical Properties | beige crystalline powder | | Uses | 2-Mercaptobenzoxazole is used in the surface treatment of materials. It is utilized for protection of metals from corrosion. | | Application | 2-Mercaptobenzoxazole is a widely used organic scaffold in medicinal chemistry.
2-Mercaptobenzoxazole and their derivatives are known to posses several biological activities such as antibacterial, antifungal, antiinflammatory, insecticidal and herbicidal. 4-0xo-thiazolidines have also played an important activities as analgesic, anti-HIV, antitubercular, anthelmentic, dye-stuffs, fluorescent and as a photosensitizer. The incorporation of 4-oxothiazolidine and their 5-arylidene moieties in 2-mercaptobenzoxazole frame work has been found to enhance the activity. | | Preparation | 2-Mercaptobenzoxazole has already been described in 1876 by Dunner (Ber. 9, (1876) page 465). 2-Mercaptobenzoxazole and its derivatives are prepared by processes which are based in principle on the reaction between o-aminophenol and alkali metal alkylxanthates. The alkali metal alkylxanthate here can either be employed as such, or it can be produced in the reaction mixture itself from an alkali, a lower alkanol and carbon disulphide.
https://patents.google.com/patent/US4677209A/en | | Definition | ChEBI: 2-mercapto-1,3-benzoxazole is a benzoxazole. | | Reactions | 2-Mercaptobenzoxazole with ethyl chloroacetate and anhydrous K2C03 in the presence of dry acetone was refluxed on water bath to give ethyl-2-(mercaptobenzoxazolo)acetate. | | Synthesis | 1. 15 mL of ethanol, 3 mL of water, 10 mmol of o-aminophenol, 10 mmol of carbon disulfide, and 10 mmol of potassium hydroxide were sequentially added to the reaction flask.
2. The reaction mixture was heated to 80 °C and stirred at reflux for 3 hours at this temperature.
3. Upon completion of the reaction, a small amount of zeolite was added to the mixture and filtered while hot.
4. Warm the filtrate to 70 °C and slowly pour it into a beaker containing 10 mL of warm water (preheated to 60-70 °C).
5. cool the beaker in an ice-water bath to induce precipitation of the product.
6. The precipitated white transparent needle-like crystals were collected by filtration and dried to give 1.23 g of 2-mercaptobenzoxazole in 81% yield. | | References | [1] Patent: CN108794421, 2018, A. Location in patent: Paragraph 0024; 0025; 0027
[2] Heteroatom Chemistry, 2001, vol. 12, # 3, p. 151 - 155
[3] Letters in Organic Chemistry, 2010, vol. 7, # 7, p. 519 - 527
[4] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 21, p. 5374 - 5379
[5] Journal of Medicinal Chemistry, 1994, vol. 37, # 7, p. 913 - 923 |
| | 2-Mercaptobenzoxazole Preparation Products And Raw materials |
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