河豚毒素鹼 基本信息
| 中文名稱 | 河豚毒素鹼 |
|---|---|
| 中文同義詞 | 河豚毒素鹼;河豚毒素檸檬酸酯鹽 |
| 英文名稱 | TETRODOTOXIN CITRATE |
| 英文同義詞 | TETRODOTOXIN CITRATE;OCTAHYDRO-12-(HYDROXYMETHYL)-2-IMINO-5,9:7,10A-DIMETHANO-10AH-[1,3]DIOXOCINO[6,5-D]PYRIMIDINE-4,7,10,11,12-PENTOL CITRATE;citratodetetrodotoxina;tetrodotoxin,citrate(1:1)(salt);Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentolcitrat;Citrato de tetrodotoxina [spanish];Tetrodotoxin, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt) (9ci);Tetrodotoxin(TTX), with citrate |
| CAS號 | 18660-81-6 |
| 分子式 | C11H17N3O8.C6H8O7 |
| 分子量 | 511.39 |
| EINECS號 | 689-001-0 |
| 相關(guān)類別 | Sodium channel |
| Mol文件 | 18660-81-6.mol |
| 結(jié)構(gòu)式 |  |
河豚毒素鹼 性質(zhì)
| 儲存條件 | Desiccate at -20°C |
|---|---|
| 溶解度 | 檸檬酸鹽緩沖液 (pH 4.8)：30 mg/ml (100 mM) |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 8.76(at 25℃) |
| 水溶解性 | Soluble to 100 mM in water |
| 穩(wěn)定性 | 在酸性溶液中不穩(wěn)定 |
安全信息
| 危險品標志 | T+ |
|---|---|
| 危險類別碼 | 26/27/28 |
| 安全說明 | 22-36/37/39-45 |
| RTECS號 | IO1450000 |
| 毒性 | A toxin contained in the ovary and liver of puffer fish, in the eggs of the California newt and in some other animals. It is used as a chemical tool for the study of ion channels. The s.c. LD50 in mice is 10 mg/kg. It is a toxicant of nerve and muscle by blocking sodium channels, this action causing nerve and muscle paralysis. Symptoms include weakening of voluntary muscles, respiratory failure from paralysis of the diaphragm and hypotension. There is no antidote. Therapy involves artificial respiration. |