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(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester Suppliers list
Company Name: Beijing Lianben Pharm-Chemicals Tech. Co.,Ltd
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Products Intro: Product Name:(5R-cis)-Toluene-4-sulfonicacid5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester
CAS:149809-43-8
Purity:0.99 Package:25KG；1KG
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Products Intro: Product Name:posaconazole impurity 13
CAS:149809-43-8
Purity:98% Package:10mg|25mg|50mg
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Products Intro: Product Name:posaconazole impurity 13
CAS:149809-43-8
Purity:98% Package:1kg;
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Products Intro: Product Name:(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester
CAS:149809-43-8
Purity:NLT 98% Package:1G;1KG;100KG
Company Name: Shanghai Daken Advanced Materials Co.,Ltd
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Products Intro: Product Name:(5R-cis)-Toluene-4-Sulfonic acid 5-(2,4-Difluorophenyl)-5-( 1H- 1,2,4-Triazole- 1-base)Methyltetrahydrofuran-3-methyl ester
CAS:149809-43-8
Purity:0.99 Package:5KG;1KG

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester manufacturers
(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester Basic information
Product Name:(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester
Synonyms:Posaconazole InterMediate;Posaconazole Main Ring;(3S,5R)-5-(2,4-Difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]oxolan-3-ylmethyl p-Toluenesulfonate;Posaconazole int1;Posaconazole Intermediate1;Posa-12 ((3S,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate;((3S,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)-tetrahydrofuran-3-yl)methyl;(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester
CAS:149809-43-8
MF:C21H21F2N3O4S
MW:449.47
EINECS:1308068-626-2
Product Categories:Aromatics;Chiral Reagents;Intermediates;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:149809-43-8.mol
(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester Structure
(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester Chemical Properties
Melting point 100-102°C
Boiling point 608.1±65.0 °C(Predicted)
density 1.40
storage temp. -20°C Freezer, Under Inert Atmosphere
solubility slightly sol. in Chloroform
form powder to crystal
pka2.75±0.10(Predicted)
color White to Orange to Green
InChIInChI=1S/C21H21F2N3O4S/c1-15-2-5-18(6-3-15)31(27,28)30-11-16-9-21(29-10-16,12-26-14-24-13-25-26)19-7-4-17(22)8-20(19)23/h2-8,13-14,16H,9-12H2,1H3/t16-,21-/m0/s1
InChIKeyDFWVLCJRFGIRAK-HRAATJIYSA-N
SMILESC1[C@](CN2N=CN=C2)(C2C(F)=CC(F)=CC=2)OC[C@H]1COS(=O)(=O)C1C=CC(C)=CC=1
CAS DataBase Reference149809-43-8(CAS DataBase Reference)
Safety Information
HS Code 2934.99.4400
MSDS Information
(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester Usage And Synthesis
Description(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester is a pharmaceutical intermediate ingredient for Posaconazole is one of the newest triazole antifungal agents approved by the FDA for the prevention of invasive Aspergillus and Candida infections in immunocompromised patients. Such patients include haematopoietic stem cell transplant patients with graft-versus-host disease and patients with haematological malignancies undergoing chemotherapy.
Chemical PropertiesWhite Crystalline Solid
UsesPosaconazole intermediate. Antifungal agent.
(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester Preparation Products And Raw materials
Raw materialsToluene-4-sulfonic acid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3-ylMethyl-->Tosyl chloride
Preparation ProductsO-Benzyl Posaconazole
Tag:(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester(149809-43-8) Related Product Information
Folic acid 5-Methyl-1H-benzotriazole Ethyl 2-(Chlorosulfonyl)acetate 1,2,4-Triazole Voriconazole Posaconazole 1H-Benzotriazole Ribavirin D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxyMethyl)-1-(1H-1,2,4-triazol-1-yl)- Citric acid 2-[(1S,2S)-1-ethyl-2-bezyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]- 3H-1,2,4-Triazol-3-one Ascoric Acid Posaconazole inter-8 PHENYL {4-[4-(4-HYDROXYPHENYL)PIPERAZIN-1-YL]PHENYL}CARBAMATE Posaconazole Impurity 44 Posaconazole Impurity 17 Posaconazole iMpurity 4 Posaconazole DiastereoisoMer interMediate 2