39224-65-2

28443-57-4

The general procedure for the synthesis of 2-hydroxy-4,5-dichloroaniline from 4,5-dichloro-2-nitrophenol was as follows: to a stirred mixed solution of 4,5-dichloro-2-nitrophenol (15 g, 72 mmol) in acetic acid (150 mL) and water (450 mL) was added powdered iron (16 g, 285 mmol) in batches. The reaction mixture was stirred continuously at 50 °C for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subjected to filtration operation and the filter cake was washed with ethyl acetate. The filtrate was subsequently extracted with ethyl acetate. The combined organic layers were washed sequentially with water, NaHCO3 (aq.) and brine, dried over Na2SO4 and concentrated under vacuum to give the final target product 2-hydroxy-4,5-dichloroaniline (10 g, 78% yield).