108477-18-5
| 中文名稱 | 108477-18-5 |
|---|---|
| 中文同義詞 | 半胱天冬酶和細胞凋亡激活劑(UBIQUITIN ISOPEPTIDASE INHIBITOR I, G5);化合物 T17192;3,5-雙(4-硝基亞芐基)四氫-4H-硫代吡喃-4-酮 1,1-二氧化物;UBIQUITIN ISOPEPTIDASE 抑制劑I;G5,UBIQUITIN ISOPEPTIDASE抑制劑I;Ubiquitin Isopeptidase-IN-G5 (NSC-144303;NSC 144303;NSC144303) |
| 英文名稱 | 4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide |
| 英文同義詞 | 4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide;NSC-144303;Ubiquitin Isopeptidase Inhibitor I;Ubiquitin Isopeptidase Inhibitor I, G5;G5, Ubiquitin Isopeptidase Inhibitor I;Ubiquitin Isopeptidase-IN-G5;Ubiquitin Isopeptidase Inhibitor I, G5 (NSC144303);Ubiquitin Isopeptidase Inhibitor I, G5,Ubiquitin Isopeptidase Inhibitor I, G-5 |
| CAS號 | 108477-18-5 |
| 分子式 | C19H14N2O7S |
| 分子量 | 414.39 |
| EINECS號 | |
| 相關(guān)類別 | 細胞生物學試劑 |
| Mol文件 | 108477-18-5.mol |
| 結(jié)構(gòu)式 |  |
108477-18-5 性質(zhì)
| 熔點 | 233.5-234.5 °C |
|---|---|
| 沸點 | 693.0±55.0 °C(Predicted) |
| 密度 | 1.541±0.06 g/cm3(Predicted) |
| 儲存條件 | Store at -20°C,unstable in solution, ready to use. |
| 溶解度 | DMSO 中≤15mg/ml；二甲基甲酰胺中≤1mg/ml |
| 形態(tài) | 結(jié)晶固體 |
| 顏色 | 淺黃至黃色 |
Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303)是凋亡不依賴的半胱天冬酶和細胞凋亡的激活劑，對E1A和E1A/C9DN細胞的IC50值分別為1.76和1.6 μM。
IC50: 1.76 μM (E1A cells), 1.6 μM (E1A/C9DN cells)
G5 is capable of activating an apoptosome-independent apoptotic pathway. It targets the ubiquitinproteasome system by inhibiting the ubiquitin isopeptidases. G5 induces a rather unique apoptotic pathway, which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with upregulation of the BH3-only protein Noxa, stabilization of the inhibitor of apoptosis antagonist Smac, but also the involvement of the death receptor pathway. G5 is a potent apoptotic inducer showing IC 50 s of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively.
安全信息
| WGK Germany | WGK 2 |
|---|---|
| 存儲類別 | 11 - 可燃固體 |
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-100738 | 108477-18-5 Ubiquitin Isopeptidase Inhibitor I, G5 | 108477-18-5 | 5mg | 770元 |
| 2025/12/22 | HY-100738 | 108477-18-5 Ubiquitin Isopeptidase Inhibitor I, G5 | 108477-18-5 | 10mg | 1330元 |