7-二甲氧基-N-(4-苯氧基苯基)- 氨基喹唑啉
| 中文名稱 | 7-二甲氧基-N-(4-苯氧基苯基)- 氨基喹唑啉 |
|---|---|
| 中文同義詞 | 7-二甲氧基-N-(4-苯氧基苯基)- 氨基喹唑啉;6,7-二甲氧基-N-(4-苯氧基苯基)-4-喹唑啉胺;SRC抑制劑1;化合物SRC INHIBITOR 1;6,7-二甲氧基-N-(4-苯氧基苯基)喹唑啉-4-胺;6,7-二甲氧基-N-(4-苯氧基苯基)- 氨基喹唑啉;SRC KINASE抑制劑I (SKI-1);化合物SRC INHIBITOR 1,10 MM DMSO 溶液 |
| 英文名稱 | 6,7-Dimethoxy-N-(4-phenoxyphenyl)- |
| 英文同義詞 | 6,7-Dimethoxy-N-(4-phenoxyphenyl)-;Src I1;SKI-1;Src Inhibitor-1;Src-l1;ANTI-HHAT (N-TERM) antibody produced in rabbit;HHAT;MART2 |
| CAS號(hào) | 179248-59-0 |
| 分子式 | C22H19N3O3 |
| 分子量 | 373.4 |
| EINECS號(hào) | |
| 相關(guān)類別 | 合成;細(xì)胞生物學(xué)試劑;標(biāo)準(zhǔn)品;Amines;Aromatics;Heterocycles;Inhibitors |
| Mol文件 | 179248-59-0.mol |
| 結(jié)構(gòu)式 |  |
7-二甲氧基-N-(4-苯氧基苯基)- 氨基喹唑啉 性質(zhì)
| 儲(chǔ)存條件 | 2-8°C |
|---|---|
| 溶解度 | 二甲基亞砜：>10mg/mL |
| 形態(tài) | 白色粉末 |
| 顏色 | 白色或灰白色 |
| 生物來(lái)源 | rabbit |
| 穩(wěn)定性 | 自購(gòu)買之日起 2 年內(nèi)保持穩(wěn)定。 DMSO 溶液可在 -20°C 下保存長(zhǎng)達(dá) 1 周。 |
| InChI | 1S/C22H19N3O3/c1-26-20-12-18-19(13-21(20)27-2)23-14-24-22(18)25-15-8-10-17(11-9-15)28-16-6-4-3-5-7-16/h3-14H,1-2H3,(H,23,24,25) |
| InChIKey | DMWVGXGXHPOEPT-UHFFFAOYSA-N |
| SMILES | COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC |
Src Inhibitor 1是Src和Lck的競(jìng)爭(zhēng)性抑制劑，IC50分別為44 nM和88 nM。它也能抑制Csk和Yes。
| Target | Value |
|
Src
(Cell-free assay) | 44 nM |
|
Lck
(Cell-free assay) | 88 nM |
Src-I1 is competitive with both ATP and peptide binding sites of the kinase. The IC 50 values are 44 and 88 nM for Src and Lck, respectively. Src-I1, is found to be a potent inhibitor of Src (IC 50 =0.18 μM), but also inhibited other Src family members, such as Lck, Csk and Yes with similar potency to Src, and RIP2 (IC 50 =0.026 μM) with even greater potency. In addition, it inhibited CHK2 with similar potency to Src, and Aurora B with slightly lower potency.
安全信息
| 危險(xiǎn)品標(biāo)志 | Xn |
|---|---|
| 危險(xiǎn)類別碼 | 22-36/37/38 |
| 安全說(shuō)明 | 26 |
| 危險(xiǎn)品運(yùn)輸編號(hào) | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| 存儲(chǔ)類別 | 11 - 可燃固體 |
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/03/03 | S6567 | 7-二甲氧基-N-(4-苯氧基苯基)- 氨基喹唑啉 Src Inhibitor 1 | 179248-59-0 | 5mg | 795.42元 |
| 2026/03/03 | S6567 | 7-二甲氧基-N-(4-苯氧基苯基)- 氨基喹唑啉 Src Inhibitor 1 | 179248-59-0 | 25mg | 2433.21元 |