TCN-201
| 中文名稱 | TCN-201 |
|---|---|
| 中文同義詞 | 4-[[[(3-氯-4-氟苯基)磺?；鵠氨基]甲基]苯甲酸 2-苯甲?；ｋ?N-(4-(2-苯甲酰肼羰基)芐基)-3-氯-4-氟苯磺酰胺;TCN 201 試劑;TCN 201 試劑 |
| 英文名稱 | 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide |
| 英文同義詞 | 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide;TCN 201;N-(4-(2-benzoylhydrazinecarbonyl)benzyl)-3-chloro-4-fluorobenzenesulfonaMide;4-[[[(3-Chloro-4-fluorophenyl)sulfonyl]aMino]Methyl]benzoic Acid 2-Benzoylhydrazide;TCN 201-d5;TCN-201 N-(4-(2-benzoylhydrazinecarbonyl)benzyl)-3-chloro-4- fluorobenzenesulfonaMide;3-Chloro-4-fluoro-N-[(4-{[2-(phenylcarbonyl)hydrazino]carbonyl}phenyl)methyl]benzenesulfonamide;N-[[4-(benzamidocarbamoyl)phenyl]methyl]-3-chloro-4-fluorobenzenesulfonamide |
| CAS號(hào) | 852918-02-6 |
| 分子式 | C21H17ClFN3O4S |
| 分子量 | 461.89 |
| EINECS號(hào) | |
| 相關(guān)類別 | Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds |
| Mol文件 | 852918-02-6.mol |
| 結(jié)構(gòu)式 |  |
TCN-201 性質(zhì)
| 儲(chǔ)存條件 | 2-8°C |
|---|---|
| 溶解度 | DMSO：可溶，5mg/mL（澄清溶液） |
| 形態(tài) | 粉末 |
| 顏色 | 白色至米色 |
| InChI | 1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28) |
| InChIKey | FYIBXBFDXNPBSF-UHFFFAOYSA-N |
| SMILES | Fc1ccc(cc1Cl)S(=O)(=O)NCc2ccc(cc2)C(=O)NNC(=O)c3ccccc3 |
pIC50: 6.8 (GluN1/GluN2A NMDA receptor)
TCN 201 (compound 1) is selective for GluN1/GluN2A NMDAR over GluN1/GluN2B NMDAR, with pIC
50
s of 6.8 and <4.3, respectively.
TCN 201 (10 μM) produces only slight inhibition of GluN1/GluN2B NMDAR-mediated currents in oocytes.
TCN 201 (10-30 μM) antagonism of NMDAR-mediated responses is both subtype- and glycine-dependent and more potent than TCN 213 in oocytes.
TCN 201 (0.1-100 μM) does not produce complete block of NMDAR-mediated responses in oocytes.
TCN 201 (10 μM) antagonism of NMDAR-mediated currents shows a negative correlation with their ifenprodil sensitivity in rat cortical neurons.
TCN 201 (1-9 μM) suppresses cortical spreading depression (CSD) in chick retina.
TCN-201 (10 mg/kg; i.p.) is ineffective in CSD blood-oxygen level-dependent (BOLD) response in rats.
安全信息
| 危險(xiǎn)品標(biāo)志 | Xi |
|---|---|
| 危險(xiǎn)類別碼 | 22-36/37/38 |
| 安全說(shuō)明 | 26-36/37/39 |
| WGK Germany | 3 |
| 存儲(chǔ)類別 | 11 - 可燃固體 |
| 危險(xiǎn)性類別 | 眼部刺激 類別2 經(jīng)皮刺激 類別2 特異性靶器官毒性-一次接觸，類別3 |
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/07/06 | S0446 | TCN-201 TCN 201 | 852918-02-6 | 5mg | 3988.53元 |
| 2026/07/06 | S0446 | TCN-201 TCN 201 | 852918-02-6 | 25mg | 12031.1元 |