| Company Name: |
J & K SCIENTIFIC LTD.
|
| Tel: |
18210857532; 18210857532 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:PU-H71 Hydrate
CAS:1202865-65-3
Package:50Mg,5Mg
|
| Company Name: |
Chemsky (shanghai) International Co.,Ltd
|
| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:PU-H71 Hydrate;6-AMino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-Methylethyl)-9H-purine-9-propanaMine Hydrate;
CAS:1202865-65-3
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
|
PU-H71 Hydrate manufacturers
- PU-H71 hydrate
-
- $1520.00
-
2026-04-21
- CAS:1202865-65-3
- Purity:
- Supply Ability: 10g
|
| | PU-H71 Hydrate Basic information |
| | PU-H71 Hydrate Chemical Properties |
| solubility | DMF: 12 mg/ml
DMF: PBS(pH 7.2)(1:1): 0.5 mg/ml
DMSO: 10 mg/ml |
| | PU-H71 Hydrate Usage And Synthesis |
| Uses | PU-H71 is a potent Hsp90 inhibitor (IC50 = 50 nM). Hsp90 plays a critical role in modulating the activity of many cell signaling proteins and are an attractive target for anti-cancer therapeutics. Studies indicate that Hsp90 inhibitors may serve as potential anti-Parkinson′s disease. | | References | [1] HUAZHONG HE. Identification of Potent Water Soluble Purine-Scaffold Inhibitors of the Heat Shock Protein 90[J]. Journal of Medicinal Chemistry, 2005, 49 1: 381-390. DOI: 10.1021/jm0508078
[2] SAAD Z USMANI. The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1.[J]. Journal of Hematology & Oncology, 2010, 3: 40. DOI: 10.1186/1756-8722-3-40
[3] ELOISI CALDAS-LOPES. Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2009, 106 20: 8368-8373. DOI: 10.1073/pnas.0903392106 |
| | PU-H71 Hydrate Preparation Products And Raw materials |
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