| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Amiodarone-D4 hydrochloride solution
CAS:1216715-80-8
Purity:100 mug/mL in methanol (as free base), ampule of 1 mL, certi Package:1ML Remarks:A-083-1ML
|
| Company Name: |
Shenzhen SUNGENING Bio-Medical Co., Ltd.
|
| Tel: |
0755-28967200 13631290199 |
| Email: |
wxf@sungening.com |
| Products Intro: |
Product Name:Amiodarone-D4 HCl
CAS:1216715-80-8
Purity:99% HPLC or More Package:10MG;25MG;50MG;100MG
|
Amiodarone-D4 HCl manufacturers
|
| | Amiodarone-D4 HCl Basic information |
| Product Name: | Amiodarone-D4 HCl | | Synonyms: | Amiodarone-D4 hydrochloride solution;(2-butyl-1-benzofuran-3-yl)-[3,5-diiodo-4-[1,1,2,2-tetradeuterio-2-(diethylamino)ethoxy]phenyl]methanone:hydrochloride;[2H4]-Amiodarone Hydrochloride;AMIODARONE HCL (D4, 98%) 100 UG/ML IN METHANOL (AS FREE BASE);Amiodarone hydrochloride salt;Amiodarone D4 HydrochlorideQ: What is
Amiodarone D4 Hydrochloride Q: What is the CAS Number of
Amiodarone D4 Hydrochloride Q: What is the storage condition of
Amiodarone D4 Hydrochloride Q: What are the applications of
Amiodarone D4 Hydrochloride;2H4]-Amiodarone hydrochloride salt;Prosulfocarb Impurity 3-d10 | | CAS: | 1216715-80-8 | | MF: | C25H30ClI2NO3 | | MW: | 681.78 | | EINECS: | 806-400-9 | | Product Categories: | | | Mol File: | 1216715-80-8.mol |  |
| | Amiodarone-D4 HCl Chemical Properties |
| Fp | 9℃ | | storage temp. | -20°C | | solubility | DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 5 mg/ml | | form | A solid | | color | White to off-white | | Stability: | Very Hygroscopic | | Major Application | clinical testing | | InChIKey | ITPDYQOUSLNIHG-MMJSDMDPSA-N | | SMILES | Cl.[2H]C([2H])(Oc1c(I)cc(cc1I)C(=O)c2c(CCCC)oc3ccccc23)C([2H])([2H])N(CC)CC |
| Hazard Codes | F,T | | Risk Statements | 11-23/24/25-39/23/24/25 | | Safety Statements | 7-16-36/37-45 | | RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | | WGK Germany | 1 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Flam. Liq. 2
STOT SE 1 |
| | Amiodarone-D4 HCl Usage And Synthesis |
| Description | Amiodarone-d4 is intended for use as an internal standard for the quantification of amiodarone by GC- or LC-MS. Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents. It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 μM. In addition, amiodarone binds with high affinity to the sigma-1 opioid receptor, 3-β-hydroxysteroid Δ8Δ7 isomerase, and C-8 sterol isomerase (Kis = 1, 25, and 62 nM, respectively) and inhibits human thyroid hormone receptors α and β (IC50s = 0.6 and 0.65 μM, respectively). It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 in vitro at low micromolar concentrations. | | Uses | A Labelled non-selective ion channel blocker. Antiarrhythmic (class III). | | General Description | A Certified Spiking Solutionand stable-labeled internal standard for use in therapeutic drug monitoring analyses by LC/MS. Amiodarone, an antiarrhythmic agent marketed as Pacerone, Cordarone, Aratac, Atlansil, is monitored by clinical labs to ensure patients remain within the drug′s therapeutic range. | | References | [1] T. J. CAMPBELL K. M W. Therapeutic drug monitoring: antiarrhythmic drugs[J]. British journal of clinical pharmacology, 2003, 46 4: 307-319. DOI: 10.1046/j.1365-2125.1998.t01-1-00768.x
[2] NANDITA SINHA Srikanta S. Predicting hERG activities of compounds from their 3D structures: Development and evaluation of a global descriptors based QSAR model[J]. European Journal of Medicinal Chemistry, 2011, 46 2: Pages 618-630. DOI: 10.1016/j.ejmech.2010.11.042
[3] CHRISTIAN LAGGNER. Discovery of High-Affinity Ligands of σ1 Receptor, ERG2, and Emopamil Binding Protein by Pharmacophore Modeling and Virtual Screening[J]. Journal of Medicinal Chemistry, 2005, 48 15: 4754-4764. DOI: 10.1021/jm049073+
[4] BO CARLSSON. Synthesis and Preliminary Characterization of a Novel Antiarrhythmic Compound (KB130015) with an Improved Toxicity Profile Compared with Amiodarone[J]. Journal of Medicinal Chemistry, 2002, 45 3: 623-630. DOI: 10.1021/jm001126+
[5] THOMAS M POLASEK. Mechanism-based inactivation of human cytochrome P4502C8 by drugs in vitro.[J]. Journal of Pharmacology and Experimental Therapeutics, 2004, 311 3: 996-1007. DOI: 10.1124/jpet.104.071803 |
| | Amiodarone-D4 HCl Preparation Products And Raw materials |
|