- XEN445
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- $33.00
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2026-05-11
- CAS:1515856-92-4
- Purity: 99.75%
- Supply Ability: 10g
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| Product Name: | XEN445 | | Synonyms: | XEN 445, >=98%;XEN445 2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid;(S)-2-(3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)benzoic acid;2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid XEN445;XEN445;(S)-2-(3-(PYRIDIN-2-YLMETHOXY)PYRROLIDIN-1-YL)-5-(TRIFLUOROMETHYL)BENZOIC ACID. HCL;2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid;2-[(3S)-3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acid | | CAS: | 1515856-92-4 | | MF: | C18H17F3N2O3 | | MW: | 366.33 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 1515856-92-4.mol |  |
| | XEN445 Chemical Properties |
| Boiling point | 490.9±45.0 °C(Predicted) | | density | 1.40±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 25 mg/ml; Ethanol: 14 mg/ml | | form | A crystalline solid | | pka | 3.35±0.36(Predicted) | | color | Light brown to brown | | InChI | 1S/C18H17F3N2O3/c19-18(20,21)12-4-5-16(15(9-12)17(24)25)23-8-6-14(10-23)26-11-13-3-1-2-7-22-13/h1-5,7,9,14H,6,8,10-11H2,(H,24,25)/t14-/m0/s1 | | InChIKey | NBGRERFNOKZQLO-AWEZNQCLSA-N | | SMILES | FC(F)(F)c1cc(c(cc1)N2C[C@H](CC2)OCc3ncccc3)C(=O)O |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | XEN445 Usage And Synthesis |
| Description | Endothelial lipase, a member of the triglyceride lipase gene family expressed in endothelial cells, prefers phospholipid-enriched high-density lipoprotein (HDL) over triglyceride as a substrate. XEN445 is an endothelial lipase inhibitor (IC50 = 237 nM) that demonstrates selectivity for endothelial lipase compared to lipoprotein and hepatic lipases (IC50s = 20 and 9.5 μM, respectivley). An oral dose of 30 mg/kg XEN445 is reported to increase HDL cholesterol concentrations by 16% after three days and by 30% after nine days dosing in wild-type mice. | | Uses | XEN445 is a potent and selective endothelial lipase inhibitor. | | References | [1] SHAOYI SUN . Discovery of XEN445: A potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice[J]. Bioorganic & Medicinal Chemistry, 2013, 21 24: Pages 7724-7734. DOI: 10.1016/j.bmc.2013.10.023 |
| | XEN445 Preparation Products And Raw materials |
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