| Company Name: |
Amatek Scientific Co. Ltd.
|
| Tel: |
0512-56316828 4008675858 |
| Email: |
sales@amateksci.com |
| Products Intro: |
Product Name:3-Azetidineacetic acid methyl ester HCl
CAS:1229705-59-2
Purity:97% HPLC Package:1g;5g;25g;100g
|
|
| | Azetidin-3-yl-acetic acid methyl ester hydrochloride Basic information |
| Product Name: | Azetidin-3-yl-acetic acid methyl ester hydrochloride | | Synonyms: | Azetidin-3-yl-acetic acid methyl ester hydrochloride;3-Azetidineacetic acid methyl ester HCl;methyl 2-(azetidin-3-yl)acetate HCl;3-Azetidineacetic Acid Methyl Ester Hydrochloride;Methyl 2-(3-Azetidinyl)acetate Hydrochloride;azetidin-3-yl-acetic acid methyl ester hydrochloride salt | | CAS: | 1229705-59-2 | | MF: | C6H12ClNO2 | | MW: | 165.62 | | EINECS: | | | Product Categories: | | | Mol File: | 1229705-59-2.mol |  |
| | Azetidin-3-yl-acetic acid methyl ester hydrochloride Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | Appearance | White to off-white Solid |
| | Azetidin-3-yl-acetic acid methyl ester hydrochloride Usage And Synthesis |
| Synthesis | General procedure for the synthesis of methyl 2-(azetidin-3-yl)acetate hydrochloride from tert-butyl 3-(2-methoxy-2-oxoethyl)azetidine-1-carboxylate: to tert-butyl 3-(2-methoxy-2-oxoethyl)azetidine-1-carboxylate (200 mg, 872.33 μmol, 1.00 eq.) in methanol (2 mL) at 0 °C A 4 M solution of methanolic hydrochloric acid (2 mL, 9.17 eq.) was slowly added to the solution. The reaction mixture was stirred at 25 °C for 2 hours. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure to afford the crude product methyl 2-(azetidin-3-yl)acetate hydrochloride (112 mg, 867.14 μmol). The structure of the product was confirmed by 1H NMR (400 MHz, CD3OD) with characteristic peaks located at δ 4.16 (t, J=9.9 Hz, 2H), 3.95-3.87 (m, 2H), 3.73-3.65 (m, 3H), 3.28-3.19 (m, 1H), 2.78-2.69 (m, 2H). | | References | [1] Patent: WO2016/172496, 2016, A1. Location in patent: Paragraph 00183-00184 |
| | Azetidin-3-yl-acetic acid methyl ester hydrochloride Preparation Products And Raw materials |
|