2-((2-氧代-2-(噻吩-2-基)乙基)硫基)-4,6-二(噻吩-2-基)吡啶-3-腈
| 中文名稱 | 2-((2-氧代-2-(噻吩-2-基)乙基)硫基)-4,6-二(噻吩-2-基)吡啶-3-腈 |
|---|---|
| 中文同義詞 | 人直腸腺癌腺癌細(xì)胞;化合物RCM-1;2-((2-氧代-2-(噻吩-2-基)乙基)硫基)-4,6-二(噻吩-2-基)吡啶-3-腈;RCM-1人胰腺癌細(xì)胞;RCM-1人直腸腺癌腺癌細(xì)胞;人直腸腺癌細(xì)胞 RCM-1;RCM-1人直腸腺癌細(xì)胞;RCM 1,FOXM1抑制劑 |
| 英文名稱 | troponin I type 3 (cardiac) |
| 英文同義詞 | Anti-TNNI3 antibody produced in goat;CMD1FF;CMD2A;CMH7;RCM1;troponin I type 3 (cardiac);Monoclonal Anti-TNNI3 antibody produced in mouse;2-((2-Oxo-2-(thiophen-2-yl)ethyl)thio)-4,6-di(thiophen-2-yl)nicotinonitrile |
| CAS號 | 339163-65-4 |
| 分子式 | C20H12N2OS4 |
| 分子量 | 424.58 |
| EINECS號 | |
| 相關(guān)類別 | 細(xì)胞-細(xì)胞系 |
| Mol文件 | 339163-65-4.mol |
| 結(jié)構(gòu)式 |  |
2-((2-氧代-2-(噻吩-2-基)乙基)硫基)-4,6-二(噻吩-2-基)吡啶-3-腈 性質(zhì)
| 沸點(diǎn) | 632.8±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.49±0.1 g/cm3(Predicted) |
| 儲存條件 | Keep in dark place,Inert atmosphere,Room temperature |
| 溶解度 | 二甲基亞砜：16.67 mg/ml（39.26 mM） |
| 酸度系數(shù)(pKa) | -1.42±0.37(Predicted) |
| 形態(tài) | 緩沖水溶液 |
| 顏色 | 米白色至灰色 |
| 生物來源 | mouse |
| InChIKey | DCCYTKKDAZEVLY-UHFFFAOYSA-N |
| SMILES | [s]1c(ccc1)c2nc(c(c(c2)c4[s]ccc4)C#N)SCC(=O)c3[s]ccc3 |
| Target | Value |
|
FOXM1
() | |
|
IL-13
() | |
|
STAT6
() | |
|
β-catenin
() |
RCM-1 blocks the nuclear localization and increased the proteasomal degradation of FOXM1, a transcription factor critical for the differentiation of goblet cells from airway progenitor cells. In cultured airway epithelial cells, RCM-1 reduces IL-13 and STAT6 signaling and prevented the expression of the STAT6 target genes Spdef and Foxa3, which are key transcriptional regulators of goblet cell differentiation.
RCM-1 reduces airway resistance, increased lung compliance, and decreased proinflammatory cytokine production in mice exposed to the house dust mite and interleukin-13 (IL-13), which triggers goblet cell metaplasia. In mice, RCM-1 reduces IL-13 and STAT6 signaling and prevented the expression of the STAT6 target genes Spdef and Foxa3.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存儲類別 | 11 - 可燃固體 |
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/07/06 | S6898 | 2-((2-氧代-2-(噻吩-2-基)乙基)硫基)-4,6-二(噻吩-2-基)吡啶-3-腈 RCM-1 | 339163-65-4 | 5mg | 1870元 |
| 2026/07/06 | S6898 | 2-((2-氧代-2-(噻吩-2-基)乙基)硫基)-4,6-二(噻吩-2-基)吡啶-3-腈 RCM-1 | 339163-65-4 | 25mg | 7170.54元 |