10,12-二十三聯(lián)炔酸
| 中文名稱 | 10,12-二十三聯(lián)炔酸 |
|---|---|
| 中文同義詞 | 10,12-二十三聯(lián)炔酸;10,12-二十三碳二炔酸;10,12-二十三碳二炔酸,96% |
| 英文名稱 | 10,12-TRICOSADIYNOIC ACID |
| 英文同義詞 | 10,12-TRICOSADIYNOIC ACID;TIMTEC-BB SBB009036;tricosa-10,12-diynoic acid;10,12-Tricosadiynoic acid >=98.0% (GC);10,12-TRICOSADIYNOIC ACID, 97%10,12-TRICOSADIYNOIC ACID, 97%10,12-TRICOSADIYNOIC ACID, 97%10,12-TRICOSADIYNOIC ACID, 97%;10,12-Tricosadiynoicaci;10,12-Tricosadiynoic acid,ROS,mono- acylglycerol acyltransferase,10,12Tricosadiynoic acid,fatty,Diacylglycerol acyltransferase,SIRT1-AMPK,Diglyceride acyltransferase,metabolic,mitochondrial,oxidation,insulin,10,12 Tricosadiynoic acid,inhibit,triglyceride,Inhibitor,Acyltransferase,acyl-CoA:cholesterol acyltransferase,acid;10,12-Tricosadiynoic acid - [T94776] |
| CAS號 | 66990-30-5 |
| 分子式 | C23H38O2 |
| 分子量 | 346.55 |
| EINECS號 | |
| 相關類別 | 自組裝和接觸印刷;Acetylenes;Acetylenic Carboxylic Acids & Their Derivatives;Diacetylene Monocarboxylic Acids;Functional Materials;LB Films |
| Mol文件 | 66990-30-5.mol |
| 結構式 | ![]() |
10,12-二十三聯(lián)炔酸 性質
| 熔點 | 56-60 °C |
|---|---|
| 儲存條件 | Refrigerator |
| 溶解度 | 二甲基亞砜:100mg/mL(288.56mM) |
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
| 水溶解性 | Insoluble in water. |
| 敏感性 | Light Sensitive |
| BRN | 1880414 |
| InChI | 1S/C23H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23(24)25/h2-10,15-22H2,1H3,(H,24,25) |
| InChIKey | DIEDVCMBPCRJFQ-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCC#CC#CCCCCCCCCC(O)=O |
| CAS 數(shù)據(jù)庫 | 66990-30-5(CAS DataBase Reference) |
Acyl-CoA oxidase-1 (ACOX1).
10,12-Tricosadiynoic acid-CoA rapidly inhibits ACOX1 activity in a time- and concentration-dependent manner. The activity of ACOX1 decreases by nearly 95% after 5 min of incubation with 10 eq of 10,12-Tricosadiynoic acid-CoA. ACOX1 activity is inhibited only if free 10,12-Tricosadiynoic Acid is activated as the CoA thioester, the substrate form. Inhibition of ACOX1 by 10,12-Tricosadiynoic acid-CoA is irreversible. And the kinetics parameters KI and kinact are calculated to be 680 nm and 3.18 min
?1
, respectively.
10,12-Tricosadiynoic acid is the precursor of 10,12-Tricosadiynoic acid-CoA and is transformed into 10,12-Tricosadiynoic acid-CoA by peroxisomal very long chain acyl-CoA synthetase (VLACS) after entering into cells, and it inhibits ACOX1 in vivo.
10,12-Tricosadiynoic acid (500 nM) inhibits acyl-CoA oxidase-1 (ACOX1) activity. 10,12-Tricosadiynoic acid treatment abrogates the protective effect by Sirt5 siRNA.
10,12-Tricosadiynoic acid (100 μg/kg; oral gavage; daily; for 8 weeks; male Wistar rats) treatment increases hepatic mitochondrial fatty acid oxidation (FAO) via activation of the SIRT1-AMPK (adenosine 5′-monophosphate-activated protein kinase) pathway and proliferator activator receptor α and reduces hydrogen peroxide accumulation in high fat diet-fed rats, which significantly decreases hepatic lipid and ROS contents, reduces body weight gain, and decreases serum triglyceride and insulin levels.
10,12-Tricosadiynoic acid (0 mg/kg, 37.5 mg/kg, 75 mg/kg, and 150 mg/kg diet) treatment does not affect weight gain, but significantly decreases peroxisomal β-oxidation in the liver, and increased body fat accumulation in Nile tilapia. The fish with impaired peroxisomal β-oxidation exhibited higher contents of serum lipid and peroxidation products, and alanine aminotransferase activity, and significantly lowered hepatic activities of superoxide dismutase and catalase.
| Animal Model: | Male Wistar rats (210-230 g) fed with high fat diet |
| Dosage: | 100 μg/kg |
| Administration: | Oral gavage; daily; for 8 weeks |
| Result: | Reduced hydrogen peroxide accumulation in high fat diet-fed rats, which significantly decreased hepatic lipid and ROS contents, reduced body weight gain, and decreased serum triglyceride and insulin levels. |
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| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/03/03 | L10231 | 10,12-二十三碳二炔酸, 96% 10,12-Tricosadiynoic acid, 96% | 66990-30-5 | 5g | 2509元 |
| 2025/12/22 | HY-135425 | 10,12-二十三聯(lián)炔酸 10,12-Tricosadiynoic acid | 66990-30-5 | 5 mg | 312元 |
