3,4-二羥基芐胺·氫溴酸
| 中文名稱 | 3,4-二羥基芐胺·氫溴酸 |
|---|---|
| 中文同義詞 | 3,4-二羥基苯甲胺氫溴酸鹽,98%;3,4-二羥基苯甲胺氫溴酸鹽;3,4-二羥基芐胺;3,4-二羥基芐胺氫溴酸鹽;4-(氨甲基)兒茶酚 氫溴酸鹽;DHBA 氫溴酸鹽;3,4-二羥基芐胺氫溴酸鹽(DHBA氫溴酸鹽、4-(氨甲基)兒茶酚氫溴酸鹽、3,4-二羥基芐胺.氫溴酸、3,4-二羥基苯甲胺氫溴酸鹽);3,4-二羥基芐胺·氫溴酸 |
| 英文名稱 | 3,4-DIHYDROXYBENZYLAMINE HYDROBROMIDE |
| 英文同義詞 | 4-(AMINOMETHYL)CATECHOL HYDROBROMIDE;3,4-DIHYDROXYBENZYLAMINE HYDROBROMIDE;DHBA HYDROBROMIDE;4-(aminomethyl)pyrocatechol hydrobromide;3,4-DIHYDROXYBENZYLAMINE HYDROBROMIDE, 9 8%;4-(Aminomethyl)catechol hydrobromide, DHBA hydrobromide;3,4-Dihydroxybenzylamine·hydrogen bromide;4-(Aminomethyl)pyrocatechol·hydrobrominate |
| CAS號(hào) | 16290-26-9 |
| 分子式 | C7H10BrNO2 |
| 分子量 | 220.06 |
| EINECS號(hào) | 240-382-8 |
| 相關(guān)類別 | 中藥對(duì)照品;Anilines, Aromatic Amines and Nitro Compounds |
| Mol文件 | 16290-26-9.mol |
| 結(jié)構(gòu)式 |  |
3,4-二羥基芐胺·氫溴酸 性質(zhì)
| 熔點(diǎn) | 184-186 °C(lit.) |
|---|---|
| 儲(chǔ)存條件 | Inert atmosphere,Room Temperature |
| 溶解度 | 可溶于DMSO（輕微）、甲醇（非常輕微） |
| 形態(tài) | 結(jié)晶粉末 |
| 顏色 | 淺米色低熔點(diǎn) |
| 敏感性 | Hygroscopic |
| BRN | 4002646 |
| InChI | 1S/C7H9NO2.BrH/c8-4-5-1-2-6(9)7(10)3-5;/h1-3,9-10H,4,8H2;1H |
| InChIKey | BVFZTXFCZAXSHN-UHFFFAOYSA-N |
| SMILES | Br.NCc1ccc(O)c(O)c1 |
| CAS 數(shù)據(jù)庫(kù) | 16290-26-9(CAS DataBase Reference) |
3,4-Dihydroxybenzylamine hydrobromide (1 μM-10 mM; 48 hours) inhibits the growth of all melanoma cell lines with an IC 50 of 100 μM, while the SK-MELB cell line exhibits an IC 50 of 122 μM. The IC 50 values are 30, 84,90, and 68 μM for Human SK-MEL-30, SK-MEL-2, SK-MEL-3,RPMI-7951 cells, respectively. It exhibits IC 50 values of 10, 25, 67, and 184 μM for S91A,S91B, L1210, and SCC-25 cells, respectively.3,4-Dihydroxybenzylamine hydrobromide (1 μM-10 mM; 48 hours) cytotoxicity in SK-MEL-2 and SK-MEL-28 cell lines can be enhanced by application of buthionine sulfoximine (BSO). BSO treatment sensitizes marginally pigmented cells to the effects of 3,4-DHBA, and the presence of decreses IC 50 values of 3,4-DHBA by 127% in the SK-MEL-28 cell line and by 148% in the SK-MEL-2 cell line.
Cell Viability Assay
| Cell Line: | Human and Murine Melanoma Cell Lines; Non-Melanoma Cell Lines |
| Concentration: | 1 μM-10 mM |
| Incubation Time: | 48 hours |
| Result: | Inhibited melanoma cell Lines growth. |
3,4-Dihydroxybenzylamine hydrobromide (intraperitoneal injection; 1000 mg/kg; 7 days) has the least toxic effect in non-tumor-bearing B6D2F1 mice,and mice is tolerated at this dose. 3,4-Dihydroxybenzylamine hydrobromide (intraperitoneal injection; 200-800 mg/kg; 21 days) has different effects at different doses, the median life-span are 17, 24.5, 26, 29 and 25 days for 0 mg/kg, 200 mg/kg, 400 mg/kg, 600 mg/kg, and 800 mg/kg, respectively.
| Animal Model: | C57BL/6 mice with B6D2F1 cells |
| Dosage: | 200 mg/kg, 400 mg/kg, 600 mg/kg, and 800 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Exhibited increased life-span of 44%,46%, 70% and 50% for 200 mg/kg, 400 mg/kg, 600 mg/kg, and 800 mg/kg, respectively. |
安全信息
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| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/07/06 | 22857 | 3,4-二羥基苯甲胺 氫溴酸鹽 3,4-Dihydroxybenzylamine hydrobromide, 98%, Thermo Scientific Chemicals | 16290-26-9 | 1g | 1129元 |
| 2026/06/05 | HY-N3023 | 3,4-二羥基芐胺·氫溴酸 3,4-Dihydroxybenzylamine hydrobromide | 16290-26-9 | 100mg | 500元 |