| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:ONO-0300302
CAS:856689-51-5
Package:100mg/RMB 36500;25mg/RMB 18000;50mg/RMB 23500
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| | ONO-0300302 Basic information |
| Product Name: | ONO-0300302 | | Synonyms: | ONO-0300302;1H-Pyrrole-3-propanoic acid, 1-[(2S,3S)-2-[(2,3-dihydro-1H-inden-2-yl)methyl]-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]- | | CAS: | 856689-51-5 | | MF: | C29H35NO5 | | MW: | 477.59 | | EINECS: | | | Product Categories: | | | Mol File: | 856689-51-5.mol |  |
| | ONO-0300302 Chemical Properties |
| Boiling point | 678.2±55.0 °C(Predicted) | | density | 1.20±0.1 g/cm3(Predicted) | | storage temp. | -20°C, protect from light | | solubility | DMSO : 220 mg/mL (460.65 mM; Need ultrasonic) | | form | Solid | | pka | 4.67±0.10(Predicted) | | color | Off-white to light yellow |
| | ONO-0300302 Usage And Synthesis |
| Uses | ONO-0300302 is an orally active and potent LPA1 (lysophosphatidic acid receptor 1) antagonist, with an IC50 of 0.086 μM. ONO-0300302 is a slow tight binding inhibitor, and its binding affinity increases with time, with Kd of 0.34 nM (37 °C, 2 h). ONO-0300302 can be used for benign prostatic hyperplasia (BPH) research[1]. | | Biological Activity | ONO-0300302 is an orally active and potent LPA1 (lysophosphatidic acid receptor 1) antagonist, with an IC50 of 0.086 μM. ONO-0300302 is a slow tight binding inhibitor, and its binding affinity increases with time, with Kd of 0.34 nM (37 °C, 2 h). ONO-0300302 can be used for benign prostatic hyperplasia (BPH) research[1].
ONO-0300302 shows moderate stability against rat microsomes[1].
ONO-0300302 inhibits significantly an LPA (lysophosphatidic acid receptor)-induced increase of intraurethral pressure (IUP) in rat (3 mg/kg, p.o.) and dog (1 mg/kg, p.o.) over 12 h[1]. | | in vivo | ONO-0300302 inhibits significantly an LPA (lysophosphatidic acid receptor)-induced increase of intraurethral pressure (IUP) in rat (3 mg/kg, p.o.) and dog (1 mg/kg, p.o.) over 12 h[1]. | | IC 50 | LPA1 Receptor: 0.086 μM (IC50) | | References | [1]. Terakado M, et al. Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia. ACS Med Chem Lett. 2017 Nov 20;8(12):1281-1286. |
| | ONO-0300302 Preparation Products And Raw materials |
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