Amino-Tri-(carboxyethoxymethyl)-methane manufacturers
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| | Amino-Tri-(carboxyethoxymethyl)-methane Basic information |
| Product Name: | Amino-Tri-(carboxyethoxymethyl)-methane | | Synonyms: | Amino-Tri-(carboxyethoxymethyl)-methane;Tri[(2-carboxyethoxy)methyl](amino)methane;Amino-Tri-(carboxyethoxymethyl)-methane (HCl);Propanoic acid, 3,3'-[[2-amino-2-[(2-carboxyethoxy)methyl]-1,3-propanediyl]bis(oxy)]bis-;3,3’-[[2-Amino-2-[(2-carboxyethoxy)methyl]propane-1,3-diyl]bis(oxy)]dipropanoic Acid;Amino-Tri-(carboxyethoxymethyl)-methane, TFA salt;3,3'-((2-amino-2-((2-carboxyethoxy)methyl)propane-1,3-diyl)bis(oxy))dipropionic acid | | CAS: | 174362-95-9 | | MF: | C13H23NO9 | | MW: | 337.32 | | EINECS: | | | Product Categories: | GalNAc | | Mol File: | 174362-95-9.mol |  |
| | Amino-Tri-(carboxyethoxymethyl)-methane Chemical Properties |
| Boiling point | 620.2±55.0 °C(Predicted) | | density | 1.350±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C, protect from light | | solubility | Soluble in Water, DMSO, DCM, DMF | | form | low melting solid | | pka | 3.74±0.10(Predicted) | | color | Colourless |
| | Amino-Tri-(carboxyethoxymethyl)-methane Usage And Synthesis |
| Description | Amino-Tri-(carboxyethoxymethyl)-methane is a branched molecule that is reactive towards carboxylic acids in the presence of HATU. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | | Biological Activity | Amino-Tri-(carboxyethoxymethyl)-methan is a cleavable PEG-based ADC linker that can be used to synthesize antibody drug conjugates (ADCs). It is also a PROTAC linker, belonging to the PEG class, which can be used to synthesize PROTAC molecules. | | in vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. | | target |
| | Amino-Tri-(carboxyethoxymethyl)-methane Preparation Products And Raw materials |
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