惕各酰托品因
| 中文名稱 | 惕各酰托品因 |
|---|---|
| 中文同義詞 | 惕各酰托品因;化合物 T13158;TIGLOYL PSEUDOTROPINE; TIGLYLPSEUDOTROPINE; TIGLYSSIN;化合物 TIGLOIDIN |
| 英文名稱 | tigloidine |
| 英文同義詞 | tigloidine;2-Methylcrotonic acid (1R,5S)-tropan-3β-yl ester;3α-Tigloyloxytropane;Tigloyltropine;Tiglyssin;Tigloyltropeine;Tigloidin;Tigloyl pseudotropine |
| CAS號 | 495-83-0 |
| 分子式 | C13H21NO2 |
| 分子量 | 223.314 |
| EINECS號 | 2078105 |
| 相關(guān)類別 | |
| Mol文件 | 495-83-0.mol |
| 結(jié)構(gòu)式 |  |
惕各酰托品因 性質(zhì)
| 沸點(diǎn) | 290.2±33.0 °C(Predicted) |
|---|---|
| 密度 | 1.06±0.1 g/cm3(Predicted) |
| 儲存條件 | Store at -20°C |
| 溶解度 | 溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。 |
| 形態(tài) | 油狀 |
| 酸度系數(shù)(pKa) | 10.03±0.40(Predicted) |
| 顏色 | 淺黃至黃色 |
Tigloidin 是 atropine 的類似物，具有抗膽堿能的活性。
Tigloidine hydrobromide (20-60 mg/kg, i.p.) fails to protect the mice against the lethal effect of physostigmine, but at 100 mg/kg and above, it protects 80% of the animals against the lethal effect. Tigloidine markedly prevents tremor and salivation produced by tremorine at 80-100 mg/kg, but fails to prevent these effects in doses up to 40 mg/kg. Tigloidine (up to 100 mg/kg, i.p) does not significantly affects reserpine and tetrabenazine induced sedation and ptosis in mice. Tigloidine (25-50 mg/kg, i.p.) also fails to cause any behavioral changes in the cats.