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| | ACETYL COENZYME A (C2:0) LITHIUM Basic information |
| Product Name: | ACETYL COENZYME A (C2:0) LITHIUM | | Synonyms: | ACETYL COENZYME A (C2:0) LITHIUM;Acetyl coenzyme A trilithium salt,Acetyl-S-CoA Li3;Coenzyme A, S-acetate,lithium salt (8CI,9CI);Acetyl-CoA, Acetyl-S-CoA Li3;adenosine, 5'-O-[[[[[(3R)-4-[[3-[[2-(acetylthio)ethyl]amino]-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl]oxy]hydroxyphosphinyl]oxy]hydroxyphosphinyl]-, 3'-(dihydrogen phosphate), trilithium salt;Acetyl-CoA (lithium salt);Acetyl-S-CoA,Li;Acetyl coenzyme A lithium salt[A2181] | | CAS: | 32140-51-5 | | MF: | C23H39LiN7O17P3S | | MW: | 817.52 | | EINECS: | | | Product Categories: | | | Mol File: | 32140-51-5.mol |  |
| | ACETYL COENZYME A (C2:0) LITHIUM Chemical Properties |
| storage temp. | -20°C | | solubility | H2O: soluble100mg/mL, clear, colorless | | form | powder | | color | White to off-white | | Water Solubility | H2O: soluble 100mg/mL, clear, colorless | | Stability: | Hygroscopic | | InChIKey | FTRFBNATWBKIQU-JHJDYNLLSA-K | | SMILES | [Li+].[Li+].[Li+].CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23 |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36/37 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | ACETYL COENZYME A (C2:0) LITHIUM Usage And Synthesis |
| Uses | Acetyl coenzyme A is suitable in CAT reporter assay for the measurement of chloramphenicol acetyltransferase by incubating the cell extract with 0.1 μCi [14C] chloramphenicol and 0.5mM acetyl-CoA. | | Biochem/physiol Actions | Alterations in the gene encoding acetyl-CoA have been linked to Alzheimer′s disease and mild cognitive impairment. Defects in the gene cause myasthenic syndrome associated with episodic apnea. | | in vivo | Acetyl coenzyme A lithium blunts pressure overload-induced cardiomyopathy in a mice cardiac pressure overload model by Suppressing maladaptive autophagy[2][3].
Mice deprived of food (but with access to water ad libitum) for 24 h exhibit a significant reduction in total Acetyl coenzyme A lithium levels in several organs, including the heart and muscles, corresponding to a decrease in protein acetylation levels. However, the same experimental conditions have no major effects on Acetyl coenzyme A lithium concentrations in the brain and actually increase hepatic Acetyl coenzyme A lithium and protein acetylation levels[4]. | | IC 50 | Human Endogenous Metabolite |
| | ACETYL COENZYME A (C2:0) LITHIUM Preparation Products And Raw materials |
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