| Company Name: |
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
|
| Tel: |
17702719238 18971495150; |
| Email: |
sales@sun-shinechem.com |
| Products Intro: |
Product Name:ARN14494
CAS:1037837-27-6
Purity:98% HPLC Package:50.0mg;100.0mg; 200.0mg;500mg;1g;5g; 10g
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| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:ARN 14494
CAS:1037837-27-6
Package:1removed
|
1H-Indole-5-carboxamide, 1-[1-[2-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-2-oxoethyl]-4-piperidinyl]-2,3-dihydro-N-methyl-2-oxo- manufacturers
- ARN 14494
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- $2180.00
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2026-04-21
- CAS:1037837-27-6
- Purity:
- Supply Ability: 10g
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| | 1H-Indole-5-carboxamide, 1-[1-[2-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-2-oxoethyl]-4-piperidinyl]-2,3-dihydro-N-methyl-2-oxo- Basic information |
| | 1H-Indole-5-carboxamide, 1-[1-[2-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-2-oxoethyl]-4-piperidinyl]-2,3-dihydro-N-methyl-2-oxo- Chemical Properties |
| Boiling point | 686.8±55.0 °C(Predicted) | | density | 1.252±0.06 g/cm3(Predicted) | | solubility | DMSO:2.12(Max Conc. mg/mL);5.0(Max Conc. mM)
Ethanol:21.23(Max Conc. mg/mL);50.0(Max Conc. mM) | | pka | 14.81±0.20(Predicted) | | form | Solid | | color | White to off-white |
| | 1H-Indole-5-carboxamide, 1-[1-[2-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-2-oxoethyl]-4-piperidinyl]-2,3-dihydro-N-methyl-2-oxo- Usage And Synthesis |
| Description | ARN 14494 is a potent serine palmitoyltransferase inhibitor (SPT; IC50 = 27.3 nM). ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound prevents the synthesis of proinflammatory cytokines and the oxidative stress-related enzymes iNOS and COX-2 in mouse primary cortical astrocytes. ARN 14494 is neuroprotective against β-amyloid 1-42 induced neurotoxicity in primary cortical neurons co-cultured with astrocytes. | | Uses | ARN14494 is a potent and selective serine palmitoyltransferase (SPT) inhibitor, with an IC50 of 27.3 nM. ARN14494 affects the CNS in terms of anti-inflammation and neuroprotection. ARN14494 protects neurons from β-amyloid 1-42-induced neurotoxicity through a variety of mechanisms, including anti-oxidation, anti-apoptosis, and anti-inflammation. ARN14494 can be used for Alzheimer’s disease research[1]. | | IC 50 | IL-1β; iNOS; COX-2 | | References | [1] De Vita T, et al. Inhibition of Serine Palmitoyltransferase by a Small Organic Molecule Promotes Neuronal Survival after Astrocyte Amyloid Beta 1-42 Injury. ACS Chem Neurosci. 2019 Mar 20;10(3):1627-1635. DOI:10.1021/acschemneuro.8b00556 |
| | 1H-Indole-5-carboxamide, 1-[1-[2-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-2-oxoethyl]-4-piperidinyl]-2,3-dihydro-N-methyl-2-oxo- Preparation Products And Raw materials |
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