3-BROMO-4-CHLOROANILINE

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Company Name: Hebei Chuanghai Biotechnology Co., Ltd
Tel: +8615350571055
Email: Sibel@chuanghaibio.com
Products Intro: Product Name:3-BROMO-4-CHLOROANILINE
CAS:823-54-1
Purity:99% Package:1KG;10.00;USD
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-（0）57185586718 +86-13336195806
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Products Intro: Product Name:3-Bromo-4-chloroaniline
CAS:823-54-1
Purity:98%(Min GC) Package:1G;1KG;100KG
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Products Intro: Product Name:3-Bromo-4-chloroaniline
CAS:823-54-1
Purity:0.98 Package:25KG;5KG;1KG
Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: CAS:823-54-1
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G
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Products Intro: Product Name:3-BROMO-4-CHLOROANILINE
CAS:823-54-1
Purity:99% Package:1KG;1USD

3-BROMO-4-CHLOROANILINE manufacturers
3-BROMO-4-CHLOROANILINE Basic information
Product Name:3-BROMO-4-CHLOROANILINE
Synonyms:3-BROMO-4-CHLOROANILINE;3-Bromo-4-chlorobenzenamine;3-Bromo-4-chlorophenylamine;BenzenaMine,3-broMo-4-chloro-;3-Bromo-4-chloroaniline >
CAS:823-54-1
MF:C6H5BrClN
MW:206.47
EINECS:
Product Categories:Anilines, Amides & Amines;Bromine Compounds;Chlorine Compounds
Mol File:823-54-1.mol
3-BROMO-4-CHLOROANILINE Structure
3-BROMO-4-CHLOROANILINE Chemical Properties
Melting point 82°C
Boiling point 290.6±20.0℃ (760 Torr)
density 1.722±0.06 g/cm3 (20 ºC 760 Torr)
Fp 129.5±21.8℃
storage temp. Keep in dark place,Inert atmosphere,Room temperature
form powder to crystal
pka2.89±0.10(Predicted)
color White to Brown
InChI1S/C6H5BrClN/c7-5-3-4(9)1-2-6(5)8/h1-3H,9H2
InChIKeyFVZODFVCIDBDGS-UHFFFAOYSA-N
SMILESNC1=CC=C(C(Br)=C1)Cl
Safety Information
Risk Statements 20/21/22-33
Safety Statements 36/37
RIDADR 2811
HazardClass 6.1
PackingGroup Ⅲ
HS Code 29214200
Storage Class11 - Combustible Solids
Hazard ClassificationsAcute Tox. 4 Oral
MSDS Information
3-BROMO-4-CHLOROANILINE Usage And Synthesis
Description

3-Bromo-4-chloroaniline can be used as an intermediate in pharmaceutical synthesis, such as the preparation of Vismodegib, the trade name is Erivedge, the chemical name is 2-chloro-N-(4-chloro-3 -(Pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide, developed by Curis, Genentech and Evotec in cooperation, was approved by the U.S. Food and Drug Administration (FDA) on January 30, 2012 ) marketing approval as a small molecule targeted inhibitor of the Hedgehog pathway for the treatment of basal cell carcinoma.

Uses3-Bromo-4-chloroaniline is an amine derivative and can be used as an organic reagent.
SynthesisDissolve p-chloronitrobenzene in sulfuric acid aqueous solution, slowly add bromine reagent (bromine or potassium bromate), and react to obtain 3-bromo-4-chloroaniline.
References[1] Patent: WO2005/103010, 2005, A2. Location in patent: Page/Page column 37-38
[2] Patent: WO2014/74422, 2014, A1. Location in patent: Paragraph 00183
[3] Organic Letters, 2016, vol. 18, # 11, p. 2774 - 2776
[4] Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1984, vol. 38, # 10, p. 877 - 884
[5] American Chemical Journal, 1899, vol. 22, p. 247
Tag:3-BROMO-4-CHLOROANILINE(823-54-1) Related Product Information
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