- (E)-Cardamonin
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- $30.00
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2026-07-14
- CAS:19309-14-9
- Purity: 99.07%
- Supply Ability: 10g
- Cardamonin
-
-
2023-02-24
- CAS:19309-14-9
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
- Cardamonin
-
-
2023-02-24
- CAS:19309-14-9
- Min. Order: 5mg
- Purity: Analytical Standard
- Supply Ability: 10 g
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| | CARDAMONIN Basic information |
| Product Name: | CARDAMONIN | | Synonyms: | Alpinetin chalcone;Chalcone, 2', 4'-dihydroxy-6'-methoxy-;(E)-2',4'-Dihydroxy-6'-methoxychalcone;(E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one;(E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one;2-Propen-1-one, 1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenyl-, (2E)-;CARDAMONIN(RG);(2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one | | CAS: | 19309-14-9 | | MF: | C16H14O4 | | MW: | 270.28 | | EINECS: | | | Product Categories: | Inhibitors;Chalcones | | Mol File: | 19309-14-9.mol |  |
| | CARDAMONIN Chemical Properties |
| Melting point | 199～200℃ | | Boiling point | 484.5±45.0 °C(Predicted) | | density | 1.282±0.06 g/cm3(Predicted) | | storage temp. | room temp | | solubility | DMSO: ≥20mg/mL | | pka | 7.00±0.40(Predicted) | | form | powder | | color | yellow | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 weeks. | | Cosmetics Ingredients Functions | SKIN CONDITIONING | | InChI | InChI=1S/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7+ | | InChIKey | NYSZJNUIVUBQMM-BQYQJAHWSA-N | | SMILES | C(C1=C(OC)C=C(O)C=C1O)(=O)/C=C/C1=CC=CC=C1 |
| Hazard Codes | N | | Risk Statements | 50/53 | | Safety Statements | 61-24/25 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | WGK 3 | | HS Code | 29242990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | CARDAMONIN Usage And Synthesis |
| Description | Cardamonin (19309-14-9) inhibits NF-κB activation via inhibition of IκBα degradation and phosphorylation, IκB kinase activation and NF-κB nuclear translocation.1,2 Cardamonin displays anti-inflammatory activity in various models.3Cell permeable. | | Chemical Properties | Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from cardamom. | | Uses | Cardamonin has been used as a glycogen synthase kinase 3 (GSK3) inhibitor to study its effects on β-catenin loss and gain-of-function in human preimplantation embryos. | | Definition | ChEBI: Cardamonin is a member of chalcones. | | General Description | This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG | | Biological Activity | Chalone analog that display anti-inflammatory activity. Inhibits NO and PGE 2 production from LPS- and IFN- γ -induced RAW cells and inhibits TXB 2 production via the COX-1 and COX-2 pathways. Inhibits NF- κ B activation via inhibition of I κ B α degradation and phosphorylation, I κ B kinase activation and NF- κ B nuclear translocation. | | Biochem/physiol Actions | Cardamonin is a calchone from Aplinia species (zingiberaceous plant species). Cardamonin inhibits pigmentation in melanocytes through suppression of Wnt/b-catenin signaling pathway. Cardamonin suppressed Wnt/b-catenin signaling by a mechanism involving proteasome-mediated degradation of b-catenin (GSK-3b-independent pathway). Research has shown that Cardamonin possesses anti-inflammatory activity via suppression of NF-kB nuclear translocation and Ik-Ba phosphorylation. | | storage | Store at +4°C | | References | [1] JEONG-HYUNG LEE. Blockade of nuclear factor-kappaB signaling pathway and anti-inflammatory activity of cardamomin, a chalcone analog from Alpinia conchigera.[J]. Journal of Pharmacology and Experimental Therapeutics, 2006, 316 1: 271-278. DOI:10.1124/jpet.105.092486
[2] D.A. ISRAF . Cardamonin inhibits COX and iNOS expression via inhibition of p65NF-κB nuclear translocation and Iκ-B phosphorylation in RAW 264.7 macrophage cells[J]. Molecular immunology, 2007, 44 5: Pages 673-679. DOI:10.1016/j.molimm.2006.04.025
[3] SYAHIDA AHMAD . Cardamonin, inhibits pro-inflammatory mediators in activated RAW 264.7 cells and whole blood[J]. European journal of pharmacology, 2006, 538 1: Pages 188-194. DOI:10.1016/j.ejphar.2006.03.070 |
| | CARDAMONIN Preparation Products And Raw materials |
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