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| | Methyl-4-amino-3-fluorobenzoate Basic information | | Uses |
| Product Name: | Methyl-4-amino-3-fluorobenzoate | | Synonyms: | Methyl-4-amino-3-fluorobenzoate;2-Fluoro-4-(methoxycarbonyl)aniline;Benzoic acid, 4-aMino-3-fluoro-, Methyl ester;Methyl 3-fluoro-4-aMinobenzoate;3-Fluoro-4-aminobenzoic acid methyl ester | | CAS: | 185629-32-7 | | MF: | C8H8FNO2 | | MW: | 169.15 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | Methyl-4-amino-3-fluorobenzoate Chemical Properties |
| Melting point | 109-110°C | | Boiling point | 296℃ | | density | 1.264 | | Fp | 133℃ | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | form | powder | | pka | 1.07±0.10(Predicted) | | color | White to off-white |
| | Methyl-4-amino-3-fluorobenzoate Usage And Synthesis |
| Uses | 4-Amino-3-fluorophenylcarboxylic acid methyl ester is a carboxylic acid ester derivative that can be used as a pharmaceutical intermediate. | | Chemical Properties | Brown solid | | Synthesis | General procedure for the synthesis of methyl 4-amino-3-fluorobenzoate from methyl 3-fluoro-4-nitrobenzoate: Methyl 3-fluoro-4-nitrobenzoate (2.50 g, 12.5 mmol) and Pd/C catalyst (300 mg, 10 wt%) were placed in a 1:1 EtOAc/EtOH solvent mixture (40 mL). The reaction mixture was stirred at room temperature and 1 atm hydrogen atmosphere for 16 hours. After completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure to afford methyl 4-amino-3-fluorobenzoate (2.1 g, 99% yield) as a beige solid. Mass spectrometry analysis (ES+): the theoretical molecular weight of C8H8FNO2 was 169 and the measured value was 170 [M + H]+. | | References | [1] Patent: WO2018/81276, 2018, A1. Location in patent: Page/Page column 154
[2] Patent: EP3401315, 2018, A1. Location in patent: Paragraph 0096; 0097
[3] Patent: WO2007/16392, 2007, A2. Location in patent: Page/Page column 48
[4] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 13, p. 4345 - 4359
[5] Patent: US2003/232889, 2003, A1. Location in patent: Page/Page column 15 |
| | Methyl-4-amino-3-fluorobenzoate Preparation Products And Raw materials |
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