- L-Pro-Ome.HCl
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2026-06-03
- CAS:2133-40-6
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T+
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| | Methyl L-prolinate hydrochloride Basic information |
| | Methyl L-prolinate hydrochloride Chemical Properties |
| Melting point | 69-71 °C(lit.) | | alpha | -33 º (c=1, H2O) | | Boiling point | 55 °C / 11mmHg | | density | 1.1426 (rough estimate) | | refractive index | -31.5 ° (C=1, H2O) | | storage temp. | Inert atmosphere,2-8°C | | solubility | Chloroform, Methanol (Slightly), Water (slightly) | | form | Crystalline Powder, Crystals, and/or Chunks | | color | White | | Optical Rotation | [α]20/D 31°, c = 0.5 in H2O | | Sensitive | Hygroscopic | | BRN | 3596045 | | Stability: | Hygroscopic | | Major Application | peptide synthesis | | InChI | 1S/C6H11NO2.ClH/c1-9-6(8)5-3-2-4-7-5;/h5,7H,2-4H2,1H3;1H/t5-;/m0./s1 | | InChIKey | HQEIPVHJHZTMDP-JEDNCBNOSA-N | | SMILES | Cl[H].[H][C@]1(CCCN1)C(=O)OC | | CAS DataBase Reference | 2133-40-6(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/38 | | Safety Statements | 26-37/39 | | WGK Germany | 3 | | F | 3-8-10-21 | | Hazard Note | Harmful | | HS Code | 29189900 | | Storage Class | 11 - Combustible Solids |
| | Methyl L-prolinate hydrochloride Usage And Synthesis |
| Chemical Properties | Crystalline | | Uses | L-Proline Methyl Ester Hydrochloride (cas# 2133-40-6) is a compound useful in organic synthesis. | | reaction suitability | reaction type: solution phase peptide synthesis | | Synthesis | The general procedure for the synthesis of L-proline methyl ester hydrochloride from methanol and L-proline was as follows: first, methyl (S)-pyrrolidine-2-carboxylate was prepared by reacting (S)-proline (10.2 g, 88.6 mmol) with SOCl (11.6 g, 7.10 mL, 97.5 mmol) in refluxed methanol (60 mL) for 29 hours. Upon completion of the reaction, excess solvent and SOCl were removed by distillation under reduced pressure to afford the proline ester as a gray oil (15.9 g, quantitative yield). Subsequently, 2-fluoro-1-nitrobenzene (6.92 g, 5.18 mL, 49.0 mmol) was reacted with methyl (S)-pyrrolidine-2-carboxylate (7.55 g, 45.6 mmol) prepared as described above according to the literature method to afford bright yellow crystals of L-prolinylmethyl ester hydrochloride (12.0 g, quantitative yield), which was used without further purification for subsequent The product can be used for subsequent experiments without further purification. | | References | [1] Heterocycles, 1986, vol. 24, # 4, p. 1045 - 1060
[2] Bulletin des Societes Chimiques Belges, 1994, vol. 103, # 5-6, p. 201 - 206
[3] Journal of the Chemical Society - Perkin Transactions 1, 1998, # 22, p. 3767 - 3775
[4] European Journal of Organic Chemistry, 2002, # 19, p. 3304 - 3314
[5] Tetrahedron, 2008, vol. 64, # 42, p. 9992 - 9998 |
| | Methyl L-prolinate hydrochloride Preparation Products And Raw materials |
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