Acetamide, 2-[[5-cyano-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-2-pyrimidinyl]thio]-N-(6-methyl-2-benzothiazolyl)-

Acetamide, 2-[[5-cyano-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-2-pyrimidinyl]thio]-N-(6-methyl-2-benzothiazolyl)- Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:EGFR/HER2/TS-IN-2
CAS:2444364-04-7
Package:100mg;2500USD|50mg;1980USD|25mg;1520USD
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:EGFR/HER2/TS-IN-2
CAS:2444364-04-7
Package:100mg/RMB 17500;50mg/RMB 13800;25mg/RMB 10600

Acetamide, 2-[[5-cyano-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-2-pyrimidinyl]thio]-N-(6-methyl-2-benzothiazolyl)- manufacturers
Acetamide, 2-[[5-cyano-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-2-pyrimidinyl]thio]-N-(6-methyl-2-benzothiazolyl)- Basic information
Product Name:Acetamide, 2-[[5-cyano-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-2-pyrimidinyl]thio]-N-(6-methyl-2-benzothiazolyl)-
Synonyms:Acetamide, 2-[[5-cyano-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-2-pyrimidinyl]thio]-N-(6-methyl-2-benzothiazolyl)-;EGFR/HER2/TS-IN-2
CAS:2444364-04-7
MF:C26H21N7OS2
MW:511.62
EINECS:
Product Categories:
Mol File:2444364-04-7.mol
Acetamide, 2-[[5-cyano-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-2-pyrimidinyl]thio]-N-(6-methyl-2-benzothiazolyl)- Structure
Acetamide, 2-[[5-cyano-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-2-pyrimidinyl]thio]-N-(6-methyl-2-benzothiazolyl)- Chemical Properties
density 1.41±0.1 g/cm3(Predicted)
pka8.10±0.70(Predicted)
Safety Information
MSDS Information
Acetamide, 2-[[5-cyano-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-2-pyrimidinyl]thio]-N-(6-methyl-2-benzothiazolyl)- Usage And Synthesis
UsesEGFR/HER2/TS-IN-2 (compound 17) is a potent EGFR/HER2 and TS (Thymidylate synthase) inhibitor, with IC50 values of 0.173, 0.125, and 1.12 μM, respectively. EGFR/HER2/TS-IN-2 shows cytotoxic activity against MDA-MB-231 cancer cell lines, with an IC50 of 1.69 μM[1].
IC 50HER2: 0.125 ± 0. μM (IC50); EGFR: 0.173 ± 0. μM (IC50)
References[1] Abdellatif KRA, et al. Design, synthesis, molecular docking and antiproliferative activity of some novel benzothiazole derivatives targeting EGFR/HER2 and TS. Bioorg Chem. 2020 Aug;101:103976. DOI:10.1016/j.bioorg.2020.103976
Acetamide, 2-[[5-cyano-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-2-pyrimidinyl]thio]-N-(6-methyl-2-benzothiazolyl)- Preparation Products And Raw materials
Tag:Acetamide, 2-[[5-cyano-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-2-pyrimidinyl]thio]-N-(6-methyl-2-benzothiazolyl)-(2444364-04-7) Related Product Information