GALANIN (1-13) - BRADYKININ (2-9) AMIDE
| 中文名稱(chēng) | GALANIN (1-13) - BRADYKININ (2-9) AMIDE |
|---|---|
| 中文同義詞 | M35肽;甘丙肽(1-13)-緩激肽(2-9)酰胺 |
| 英文名稱(chēng) | M35 |
| 英文同義詞 | M35;H-GLY-TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-GLY-PRO-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG-NH2;GLY-TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-GLY-PRO-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG-NH2;GALANIN (1-13)-BRADYKININ (2-9) AMIDE;GWTLNSAGYLLGPPPGFSPFR-NH2;GALANIN FRAGMENT (1-13)-BRADYKININ*FRAGMENT (2-9)AM;Galanin receptorligand M35;Galanin (1-13)-Bradykinin (2-9), amide, M35 |
| CAS號(hào) | 142846-71-7 |
| 分子式 | C107H153N27O26 |
| 分子量 | 2233.53 |
| EINECS號(hào) | |
| 相關(guān)類(lèi)別 | 多肽;Peptides for Cell Biology;Galanin receptor;Peptide;Galanins;Neuropeptides |
| Mol文件 | 142846-71-7.mol |
| 結(jié)構(gòu)式 |  |
GALANIN (1-13) - BRADYKININ (2-9) AMIDE 性質(zhì)
| 密度 | 1.472±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
|---|---|
| 儲(chǔ)存條件 | −20°C |
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
| 序列 | Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-NH2 |
Kd: 0.1 nM (galanin receptor)
Ki: 0.11 nM (human galanin receptor type 1), 2.0 nM (human galanin receptor type 2)
Galanin Receptor Ligand M35 has a dual effect on the galanin mediated inhibition of Forskolin stimulated cyclic AMP production in Rin m 5F cells. Co-applied with galanin (10 nM), Galanin Receptor Ligand M35 at low concentrations (1 nM) is able to reverse the inhibitory effect of galanin. But when present at higher concentrations (15 and 30 nM), Galanin Receptor Ligand M35 acts as a galanin receptor agonist, inhibiting the forskolin stimulated production of cAMP.
Galanin Receptor Ligand M35 (6 nM/10 μL; i.c.v.) improves the ability of the male Sprague-Dnwley rats to acquire the swim maze task.
安全信息
| 安全說(shuō)明 | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-P1840 | GALANIN (1-13) - BRADYKININ (2-9) AMIDE Galanin Receptor Ligand M35 | 142846-71-7 | 1mg | 2000元 |
| 2026/06/05 | HY-P1840 | GALANIN (1-13) - BRADYKININ (2-9) AMIDE Galanin Receptor Ligand M35 | 142846-71-7 | 5mg | 4200元 |