- Tubastatin A HCl
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- $1.00
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2019-12-23
- CAS:1310693-92-5
- Min. Order: 1g
- Purity: Min98% HPLC
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| | Tubastatin A hydrochloride Basic information |
| Product Name: | Tubastatin A hydrochloride | | Synonyms: | N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride;Tubastatin A hydrochloride;TSA HCl;Tubastatin A Hydrochloride (Also See: T897000);Tubastatin A HCl salt;N-hydroxy-4-((2-methyl-1,2,3,4-tetrahydropyrido[4,3-b]indol-5-yl)methyl)benzamide hydrochloride;N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride Tubastatin A HCl;Tubastatin A hydrochloride N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride | | CAS: | 1310693-92-5 | | MF: | C20H22ClN3O2 | | MW: | 371.87 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 1310693-92-5.mol |  |
| | Tubastatin A hydrochloride Chemical Properties |
| Melting point | >221°C (subl.) | | storage temp. | -20°C | | solubility | Soluble in DMSO or Water. | | form | powder | | color | white to tan | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months. | | InChI | InChI=1S/C20H21N3O2.ClH/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25;/h2-9,25H,10-13H2,1H3,(H,21,24);1H | | InChIKey | LJTSJTWIMOGKRJ-UHFFFAOYSA-N | | SMILES | C(C1C=CC(C(=O)NO)=CC=1)N1C2=CC=CC=C2C2CN(C)CCC1=2.Cl |
| WGK Germany | 3 | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids |
| | Tubastatin A hydrochloride Usage And Synthesis |
| Description | Tubastatin A (1310693-92-5) is a potent and highly selective inhibitor of HDAC6 (IC50= 15 nM, >1000-fold selectivity against other HDAC isoforms, approx. 60-fold versus HDAC8).1It displayed anti-inflammatory and anti-rheumatic effects in Freund’s competitive adjuvant induced animal model of inflammation.2Tubastatin A inhibited TNF-α (IC50= 272 nM) and IL-6 (IC50 = 712 nM) in LPS stimulated human THP-1 macrophages.2Tubastatin A has also been shown to have therapeutic potential for treatment of Alzheimer’s disease via altered amyloid-β load and reduced tau hyperphosphorylation.3-5 | | Uses | Tubastatin A Hydrochloride is a neuroprotective HDAC6 inhibitor and is also known to induce hyperacetylation in primary cortical neuron cultures. | | Uses | Tubastatin A Hydrochloride is an LSD1 inhibitor, which targets SOX2-expressing cancer cells. | | Biochem/physiol Actions | Tubastatin A increases the total numbers of mitochondria and restores the number of moving mitochondria in DRG neurons. It reverses the axonal loss in peripheral neurons in mouse model of Charcot-Marie-Tooth disease. Tubastatin A inhibits the deacetylation of α-tubulin in murine myoblasts. | | target | HDAC6 | | storage | Store at -20°C | | References | [1] KYLE V. BUTLER. Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A[J]. Journal of the American Chemical Society, 2010, 132 31: 10842-10846. DOI:10.1021/ja102758v
[2] SANTOSH VISHWAKARMA . Tubastatin, a selective histone deacetylase 6 inhibitor shows anti-inflammatory and anti-rheumatic effects[J]. International immunopharmacology, 2013, 16 1: Pages 72-78. DOI:10.1016/j.intimp.2013.03.016
[3] MONIKA NOACK Christiane R L Janina Leyk. HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes[J]. Glia, 2014, 62 4: 535-547. DOI:10.1002/glia.22624
[4] MAJ-LINDA SELENICA. Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition.[J]. Alzheimer’s Research & Therapy, 2014, 6 1: 12. DOI:10.1186/alzrt241
[5] LING ZHANG. Tubastatin A/ACY-1215 improves cognition in Alzheimer’s disease transgenic mice.[J]. ACS Applied Electronic Materials, 2014: 1193-1205. DOI:10.3233/jad-140066 |
| | Tubastatin A hydrochloride Preparation Products And Raw materials |
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