- COOH-PEG5-COOtBu
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2025-06-07
- CAS:1309460-29-4
- Min. Order: 1g
- Purity: >98.00%
- Supply Ability: 1g
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| | Acid-PEG5-t-butyl ester Basic information |
| Product Name: | Acid-PEG5-t-butyl ester | | Synonyms: | Acid-PEG5-t-butyl ester;COOH-PEG5-OtBu;Acid-PEG5-C2-Boc;4,7,10,13,16-Pentaoxanonadecanedioic acid, 1-(1,1-dimethylethyl) ester;HOOCCH2CH2O-PEG4-CH2CH2COOtBu;Acid-PEG5-t-Bu Ester;HOOCCH2CH2O-PEG4-CH2CH2COOtBu/4,7,10,13,16-Pentaoxanonadecanedioic acid, 1-(1,1-dimethylethyl) ester;2,2-Dimethyl-4-oxo-3,7,10,13,16,19-hexaoxadocosan-22-oic acid , Acid-PEG5-C2-Boc | | CAS: | 1309460-29-4 | | MF: | C18H34O9 | | MW: | 394.46 | | EINECS: | | | Product Categories: | peg | | Mol File: | 1309460-29-4.mol |  |
| | Acid-PEG5-t-butyl ester Chemical Properties |
| Boiling point | 495.2±45.0 °C(Predicted) | | density | 1.109±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | solubility | Soluble in Water, DMSO, DCM, DMF | | pka | 4.28±0.10(Predicted) | | form | Liquid | | color | Colorless to light yellow | | InChI | InChI=1S/C18H34O9/c1-18(2,3)27-17(21)5-7-23-9-11-25-13-15-26-14-12-24-10-8-22-6-4-16(19)20/h4-15H2,1-3H3,(H,19,20) | | InChIKey | ILIIUHKWCBCCNI-UHFFFAOYSA-N | | SMILES | C(OC(C)(C)C)(=O)CCOCCOCCOCCOCCOCCC(O)=O |
| | Acid-PEG5-t-butyl ester Usage And Synthesis |
| Description | Acid-PEG5-t-butyl ester is a PEG linker containing a t-butyl protected carboxyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | | Uses | Acid-PEG5-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Acid-PEG5-t-butyl ester Preparation Products And Raw materials |
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