| Company Name: |
Finetech Industry Limited |
| Tel: |
+86-27-8746-5837 +8619945049750 |
| Email: |
info@finetechnology-ind.com |
| Products Intro: |
Product Name:(3R,5S,6S,7S,8S,9S,10S,13R,14S,17R)-6-ethyl-17-((R)-5-hydroxypentan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol
CAS:1632118-69-4
Purity:98% Package:1g,10g,25g,100g,500g,1kg
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| | BAR 501 Basic information |
| Product Name: | BAR 501 | | Synonyms: | BAR 501;CPDD0945;BAR501, 98%, a potent and selective agonist of GPBAR1;BAR 501; BAR-501;(3R,5S,6S,7S,8S,9S,10S,13R,14S,17R)-6-ethyl-17-((R)-5-hydroxypentan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol;Inhibitor,GPBAR1,TGR5,GPCR19,G-protein coupled receptor 19,BAR-501,BAR501,G protein-coupled Bile Acid Receptor 1,inhibit;Cholane-3,7,24-triol, 6-ethyl-, (3α,5β,6β,7β)-;BAR501, 10 mM in DMSO | | CAS: | 1632118-69-4 | | MF: | C26H46O3 | | MW: | 406.64 | | EINECS: | | | Product Categories: | APIs | | Mol File: | 1632118-69-4.mol |  |
| | BAR 501 Chemical Properties |
| Boiling point | 527.6±25.0 °C(Predicted) | | density | 1.047±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:65.5(Max Conc. mg/mL);161.07(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);49.18(Max Conc. mM)
Ethanol:34.33(Max Conc. mg/mL);84.42(Max Conc. mM) | | form | A crystalline solid | | pka | 14.82±0.70(Predicted) | | color | White to off-white |
| | BAR 501 Usage And Synthesis |
| Uses | BAR501 is a potent and selective agonist of GPBAR1 with an EC50 of 1 μM. | | in vivo | Pretreating rats for 6 days with BAR501, 15 mg/kg, reduces basal portal pressure and blunts the vasoconstriction activity of norepinephrine. Pretreatment with BAR501 attenuates the hepatic vasomotor activity induced by shear stress and methoxamine. Administration of BAR501 exerts a direct vasodilatory activity in the CCl4 model. Treating mice with BAR501 at the dose of 15 mg/Kg reduces portal pressure and AST plasma levels. BAR501 attenuates endothelial dysfunction by regulating CSE expression/activity[1]. | | References | [1] Renga B, et al. Reversal of Endothelial Dysfunction by GPBAR1 Agonism in Portal Hypertension Involves a AKT/FOXOA1 Dependent Regulation of H2S Generation and Endothelin-1. PLoS One. 2015 Nov 5;10(11):e0141082. DOI:10.1371/journal.pone.0141082 |
| | BAR 501 Preparation Products And Raw materials |
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