- Uricase
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2026-06-05
- CAS:9002-12-4
- Min. Order: 1KU
- Purity: ≥10unit/mg protein
- URICASE
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- $1.00
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2026-02-02
- CAS:9002-12-4
- Min. Order: 1mg
- Purity: 99%
- Supply Ability: 50tons
- URICASE
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-
2025-12-24
- CAS:9002-12-4
- Min. Order: 1KG
- Purity: 99.0%
- Supply Ability: 1000 tons
Related articles - Uricase: Chemical properties & Uses
- Uricase is a new drug with uric acid-lowering effects, also known as Uricase and Urate Oxidase, which is characterized with a ....
- Oct 18，2019
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| | URICASE Chemical Properties |
| storage temp. | -20°C | | solubility | 5 mg/mL, clear, colorless to very faintly yellow (in enzyme dilution buffer) | | form | lyophilized powder | | color | White to off-white | | biological source | Bacillus sp. (B. fastidiosus) | | Water Solubility | Hardly soluble in water, slightly soluble in buffer alkaline solution. | | Merck | 13,9944 | | Specific Activity | 15-30units/mg protein (biuret) | | Major Application | detection | | InChIKey | VPXDHZMLJOJKOX-UHFFFAOYSA-N | | SMILES | N.OCC1OC(C(O)C1OP(O)(=O)OCC2OC(C(O)C2O)N3C=CC(=O)NC3=O)N4C=CC(=O)NC4=O | | EPA Substance Registry System | Oxidase, urate (9002-12-4) |
| Safety Statements | 24/25 | | WGK Germany | 3 | | RTECS | YU7100000 | | F | 10-21 | | TSCA | TSCA listed | | HS Code | 35079090 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Eye Irrit. 2
Repr. 1B
Resp. Sens. 1 |
| | URICASE Usage And Synthesis |
| Chemical Properties | White powder | | Uses | Uricase from Arthrobacter globiformis has been used for coating the electrodes in - biosensor fabrication for the detection of uric acid in urine samples. It has also been used for analysing the effect of Zn, Cu, Mg, and Mn ions on uricase. | | Uses | In the determination of serum and urine uric acid. | | Uses | Uricase is very important for the determination of uric acid in biological fluids. Uricase is an important medical enzyme which can be used to determine urate in clinical analysis. The enzyme Urate oxidase (UO) catalyzes the oxidation of uric acid to 5-hydroxyisourate. | | General Description | Mice deficient in uricase develop uric acid nephropathy and diabetes insipidus which can be mitigated with recombinant uricase treatment. | | Biochem/physiol Actions | Uricase catalyzes the oxidation of uric acid to 5-hydroxyisourate, which subsequently forms (S)-allantoin. It is involved in purine metabolism, urate degradation and (S)-allantoin formation . | | Description | Urate Oxidase Recombinant produced in E.Coli is a tetrameric, non-glycosylated polypeptide chain containing 302 amino acids, having a molecular formula of C1523H2383N417O462S7 and a molecular mass of 34,247 Dalton.
The cDNA coding for urate-oxidase was cloned from a strain of Aspergillus flavus . The monomer protein has no intra- or inter-disulfide bridges. | | Source | Escherichia Coli | | Background | Urate oxidase catalyzes the enzymatic oxidation (degrades) of uric acid into allantoin, an inactive and soluble metabolite, which is 5 to 10 fold more soluble than uric acid . Urate oxidase is an enzyme of the purine breakdown pathway that catalyses the oxidation of uric acid to allantoin. Uricase is present in numerous diverse organisms, but not in higher primates including human. Hyperuricaemia is most commonly associated with gout and also occurs in mammalians with malignancy, especially those with lymphoid malignancies due to rapid cell turnover and an increased rate of purine metabolism. Uricase is effective in the prevention and treatment of hyperuricaemia in mammalians with malignancy and in those who have undergone transplantation. It appears to act rapidly, safely and induces a more dramatic decrease in plasma levels of uric acid. |
| | URICASE Preparation Products And Raw materials |
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