2-[(4-chlorobenzoyl)carbamothioylamino]-4-ethyl-5-methylthiophene-3-carboxamide

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Products Intro: Product Name:PI-273
CAS:925069-34-7
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Products Intro: Product Name:PI-273
CAS:925069-34-7
Purity:98.04% Package:1mg;38USD|5mg;77USD|10mg;133USD Remarks:REAGENT;FOR LABORATORY USE ONLY
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Products Intro: Product Name:PI-273
CAS:925069-34-7
Purity:98.04% Package:1mg;38USD|5mg;77USD|10mg;133USD
Company Name: SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD  
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Products Intro: Product Name:PI-273
CAS:925069-34-7
Purity:98% Package:10mg，100mg，500mg，1g，10g
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Products Intro: Product Name:PI-273
CAS:925069-34-7
Purity:98% Package:1mg;5mg;10mg

2-[(4-chlorobenzoyl)carbamothioylamino]-4-ethyl-5-methylthiophene-3-carboxamide manufacturers

  • PI-273
  • PI-273 pictures
  • $38.00
  • 2026-07-17
  • CAS:925069-34-7
  • Purity: 99.63%
  • Supply Ability: 10g
  • PI-273
  • PI-273 pictures
  • $38.00
  • 2026-07-17
  • CAS:925069-34-7
  • Purity: 99.63%
  • Supply Ability: 10g
2-[(4-chlorobenzoyl)carbamothioylamino]-4-ethyl-5-methylthiophene-3-carboxamide Basic information
Product Name:2-[(4-chlorobenzoyl)carbamothioylamino]-4-ethyl-5-methylthiophene-3-carboxamide
Synonyms:2-[(4-chlorobenzoyl)carbamothioylamino]-4-ethyl-5-methylthiophene-3-carboxamide;2-({[(4-chlorobenzoyl)amino]carbonothioyl}amino)-4-ethyl-5-methyl-3-thiophenecarboxamide;PI-273;3-Thiophenecarboxamide, 2-[[[(4-chlorobenzoyl)amino]thioxomethyl]amino]-4-ethyl-5-methyl-;2-(3-(4-Chlorobenzoyl)thioureido)-4-ethyl-5-methylthiophene-3-carboxamide;PI4K,Inhibitor,PI4 kinases,PI 273,PI273,Apoptosis,inhibit,Phosphatidylinositol 4 kinases,PI-273;PI-273, 10 mM in DMSO;2-({[(4-Chlorophenyl)carbonyl]carbamothioyl}amino)-4-ethyl-5-methylthiophene-3-carboxamide
CAS:925069-34-7
MF:C16H16ClN3O2S2
MW:381.9
EINECS:
Product Categories:
Mol File:925069-34-7.mol
2-[(4-chlorobenzoyl)carbamothioylamino]-4-ethyl-5-methylthiophene-3-carboxamide Structure
2-[(4-chlorobenzoyl)carbamothioylamino]-4-ethyl-5-methylthiophene-3-carboxamide Chemical Properties
density 1.425±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 6.25 mg/mL (16.37 mM)
form Solid
pka8.09±0.70(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
2-[(4-chlorobenzoyl)carbamothioylamino]-4-ethyl-5-methylthiophene-3-carboxamide Usage And Synthesis
UsesPI-273 is a first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC50 of 0.47 μM. PI-273 can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis[1].
in vivo

PI-273 (intraperitoneal injection; 25 mg/kg/day; 15 days) profoundly suppresses the tumor volume and weight in the MCF-7 xenografts[1].
PI-273 (0.5 mg/kg (intravenously) or 1.5 mg/kg (intragastrically); 0.08-5 hours) has a half-life of 0.411 hours for intravenous administration and 1.321 hours for intragastrical administration, and the absolute bioavailability of PI-273 is 5.1%[1].

Animal Model:Eight-week-old male BALB/c nude mice with MCF-7 cell[1]
Dosage:25 mg/kg
Administration:Intraperitoneal injection; daily; 15 days
Result:Suppressed the tumor volume and weight in the MCF-7 xenografts.
Animal Model:Male Sprague-Dawley (SD) rats[1]
Dosage:0.5 mg/kg (intravenously) or 1.5 mg/kg (intragastrically) (Pharmacokinetic Study)
Administration:Intravenously or intragastrically; 0.08, 0.16, 0.33, 0.67, 1, 1.5, 2, 3 and 5 hours
Result:Has a half-life of 0.411 hours for intravenous administration and 1.321 hours for intragastrical administration, and the absolute bioavailability of PI-273 is 5.1%.
IC 50PI4KIIα: 0.47 μM (IC50)
References[1] Li J, et al. PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIα, Inhibits the Growth of Breast Cancer Cells. Cancer Res. 2017 Nov 15;77(22):6253-6266. DOI:10.1158/0008-5472.CAN-17-0484
2-[(4-chlorobenzoyl)carbamothioylamino]-4-ethyl-5-methylthiophene-3-carboxamide Preparation Products And Raw materials
Tag:2-[(4-chlorobenzoyl)carbamothioylamino]-4-ethyl-5-methylthiophene-3-carboxamide(925069-34-7) Related Product Information
NA 3-ALLYL-5,6-DIMETHYL-2-THIOXO-2,3-DIHYDROTHIENO[2,3-D]PYRIMIDIN-4(1H)-ONE 6-ethyl-2-sulfanylidene-1H,2H,3H,4H-thieno[2,3-d]pyrimidin-4-one 5-methyl-2-sulfanylidene-1H-thieno[2,3-d]pyrimidin-4-one 2-[(4-chlorobenzoyl)carbamothioylamino]-4-ethyl-5-methylthiophene-3-carboxamide 4H-Cyclopenta[b]thiophene-3-carboxamide, 2-[[[(4-chlorobenzoyl)amino]thioxomethyl]amino]-5,6-dihydro-