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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903 |
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3008007409@qq.com |
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Product Name:Ketoconazole-d3
CAS:1217766-70-5
Purity:CP:95%;98%atom Package:1mg Remarks:B70361
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| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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| Tel: |
400-9205774 |
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sales@glpbio.cn |
| Products Intro: |
Product Name:Ketoconazole-d3
CAS:1217766-70-5
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
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sales@chemegen.com |
| Products Intro: |
Product Name:Ketoconazole-d3
CAS:1217766-70-5
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Nanjing Shizhou Biology Technology Co.,Ltd
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025-025-85560043 17301488900 |
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info@synzest.com |
| Products Intro: |
Product Name:Ketoconazole (acetyl-d3)
CAS:1217766-70-5
Purity:95% Package:50mg；100mg
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| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
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marketing1@energy-chemical.com |
| Products Intro: |
Product Name:Ketoconazole-d3
CAS:1217766-70-5
Purity:NULL Package:50mg;5mg Remarks:NULL
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| | 2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone Basic information |
| Product Name: | 2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone | | Synonyms: | 2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone;[2H3]-Ketoconazole;Ketoconazole D3Q: What is
Ketoconazole D3 Q: What is the CAS Number of
Ketoconazole D3 Q: What is the storage condition of
Ketoconazole D3 Q: What are the applications of
Ketoconazole D3;Ketoconazole (acetyl-d3);D3-Ketoconazole;Ketoconazole-[D3] (Standard) | | CAS: | 1217766-70-5 | | MF: | C26H28Cl2N4O4 | | MW: | 531.43 | | EINECS: | | | Product Categories: | | | Mol File: | 1217766-70-5.mol | ![2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone Structure](CAS/20180601/GIF/1217766-70-5.gif) |
| | 2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Chloroform: slightly soluble; Methanol: slightly soluble | | form | A solid |
| | 2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone Usage And Synthesis |
| Description | Ketoconazole-d3 is intended for use as an internal standard for the quantification of ketoconazole by GC- or LC-MS. Ketoconazole is a broad-spectrum triazole antifungal agent that has activity against C. albicans, C. krusei, C. tropicalis, C. glabrata, C. parapsilosis, C. neoformans, and A. fumigatus strains (IC50s = 0.031-8 μg/ml).1 It inhibits the fungal cytochrome P450 (CYP) isoform CYP51, also known as lanosterol 14α-demethylase, which arrests ergosterol biosynthesis at the fungal membrane. Ketoconazole also inhibits human CYP3A4 (IC50 = 0.54 μM). Formulations containing ketoconazole have been used in the treatment of fungal infections. | | Uses | Ketoconazole-d3 is the labeled analogue of Ketoconazole (K186000), which inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor. | | References | 1. Dilmaghanian, S., Gerber, J.G., Filler, D.G., et al. Enantioselectivity of inhibition of cytochrome P450 3A4 (CYP3A4) by ketoconazole: Testosterone and methadone as substrates Chirality 16(2),79-85(2004). |
| | 2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone Preparation Products And Raw materials |
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