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| | N-(2-Cyanoethyl)-N-methylaniline Basic information |
| Product Name: | N-(2-Cyanoethyl)-N-methylaniline | | Synonyms: | 3-(methylphenylamino)-propanenitril;N-Methyl-N-Cyanoethyl Aniline;3-(METHYLPHENYLAMINO)PROPIONITRILE 97%;N-(2-CYANOETHYL)-N-METHYLANILINE / 3-(METHYLPHENYLAMINO)PROPIONITRILE;3-(N-Methyl-N-phenylamino)propiononitrile;3-(N-methylanilino)propanenitrile;N-Methyl-N-(2-cyanoethyl)aniline
3-(N-Methyl-N-phenylamino)propionitrile;3-(N-METHYLANILINO)PROPIONITRILE | | CAS: | 94-34-8 | | MF: | C10H12N2 | | MW: | 160.22 | | EINECS: | 202-325-5 | | Product Categories: | aniline derivatives;Intermediates of Dyes and Pigments | | Mol File: | 94-34-8.mol |  |
| | N-(2-Cyanoethyl)-N-methylaniline Chemical Properties |
| | N-(2-Cyanoethyl)-N-methylaniline Usage And Synthesis |
| Synthesis | An activated carbon-supported platinum catalyst (Pt / C, 0.06 mg platinum, 0.0003 mmol, 0.1 mol percent) was added to a 10 mL Schlenk tube; after the evacuation of argon, add 1 mL of solvent (toluene). Under argon protection, to the above system, Were successively added phenylsilane (78.9 mg, 0.75 mmol), 3-Anilinopropionitrile (43.9 mg, 0.3 mmol) and formic acid (27.6 mg, 0.6 mmol). The whole anti-reaction was carried out at 80 ° C with stirring for 15 hours. After completion of the reaction, 3 mL of ethyl acetate was added to the system. The reaction was quenched with aqueous sodium hydroxide (3 mol / L, 3 mL). Ethyl acetate (3 x 10 mL), the organic phase was separated, Dried over anhydrous Na2SO4, and filtered; the solvent was removed by rotary evaporation. The residue was purified by column chromatography on ethyl acetate/petroleum ether = 1: 50 mixed solvent. Separation and purification gave N-(2-Cyanoethyl)-N-methyl aniline 226.4 mg, yield of 55 per cent. | | References | [1] Journal of Organic Chemistry, 2015, vol. 80, # 20, p. 10375 - 10379
[2] Tetrahedron, 2013, vol. 69, # 6, p. 1712 - 1716
[3] Green Chemistry, 2010, vol. 12, # 5, p. 786 - 789
[4] Synthesis, 2008, # 24, p. 3931 - 3936
[5] Journal of the American Chemical Society, 1944, vol. 66, p. 725,728 |
| | N-(2-Cyanoethyl)-N-methylaniline Preparation Products And Raw materials |
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