| Company Name: |
Shanghai Huzhen Industrial Co., LTD
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| Tel: |
021-60345367 13916550749 |
| Email: |
sales@shzbio.com |
| Products Intro: |
Product Name:PTEN
Purity:> 99% Package:50ul/RMB 1138;100ul/RMB 1880 Remarks:ITGA 2; MGC11227; MHAM; MMAC 1; MMAC1; Bannayan Zonana; BZS a; Multiple hamartoma (Cowden syndrome); Mutated in Mutiple Advanced Cancers 1; Phosphatase and Tensin Homolog; Phosphat
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| Company Name: |
ZSGB-BIO
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| Tel: |
02-400-810-9781 400810978 |
| Email: |
sales@zsbio.com |
| Products Intro: |
Product Name:PTEN
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| Company Name: |
IQ Products
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| Tel: |
1-0031505757000 0031505757000 |
| Email: |
marketing@iqproducts.nl |
| Products Intro: |
Product Name:PTEN
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| Company Name: |
Wuhan Fine Biotech Co Ltd
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| Tel: |
13047170542 |
| Email: |
marketing@fn-test.com |
| Products Intro: |
Product Name:Recombinant Human PTEN
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| | Recombinant Human PTEN Basic information |
| Product Name: | Recombinant Human PTEN | | Synonyms: | MMAC1 elisa kit;Recombinant Human PTEN;5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN;PTEN human;Phosphatase and tensin homolog;Phosphatidylinositol-3;Mouse PTEN;Human PTEN | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | proteins | | Mol File: | Mol File | ![Recombinant Human PTEN Structure]() |
| | Recombinant Human PTEN Chemical Properties |
| | Recombinant Human PTEN Usage And Synthesis |
| Enzyme inhibitor | This tumor-suppressing, Mg2+-dependent dual-specificity protein phosphatase (MW = 47166 g/mol; GenBank: AAD13528.1), which catalyzes the dephosphorylation of phosphotyrosine-, phosphoserine- and phosphothreonine-containing proteins, is also a lipid phosphatase (Reaction: Phosphatidylinositol 3,4,5-trisphosphate + H2O Phosphatidylinositol 4,5-bisphosphate + Pi), with the following in vitro substrate preference: PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. PTEN antagonizes PI3K-AKT/PKB signaling by dephosphorylating phosphoinositides and reduces cell cycle progression and survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. PTEN catalyzes the dephosphorylation of tyrosine-phosphorylated focal adhesion kinase, inhibiting cell migration and integrin-mediated cell spreading. PTEN also modulates AKT-mTOR signaling. PTEN plays an essential role in the maintenance of genome stability. PTEN also dephosphorylates MCM2 and inhibits replication fork progression under replication stress, suggesting that PTEN is involved in an S-phase checkpoint. DNA molecular combing analysis revealed that replication forks in PTEN-proficient cells are subject to more efficient braking in response to fork stalling than the forks in PTEN-deficient cells. |
| | Recombinant Human PTEN Preparation Products And Raw materials |
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