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| | DNP-PEG4-DBCO Basic information |
| Product Name: | DNP-PEG4-DBCO | | Synonyms: | DNP-PEG4-DBCO;4,7,10,13-Tetraoxapentadecanamide, N-[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]-15-[(2,4-dinitrophenyl)amino]- | | CAS: | 2149585-17-9 | | MF: | C35H39N5O10 | | MW: | 689.71 | | EINECS: | | | Product Categories: | | | Mol File: | 2149585-17-9.mol |  |
| | DNP-PEG4-DBCO Chemical Properties |
| Boiling point | 947.1±65.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | pka | 15.14±0.46(Predicted) | | form | Oil | | color | Light yellow to yellow |
| | DNP-PEG4-DBCO Usage And Synthesis |
| Uses | DNP-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DNP-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | | Biological Activity | DNP-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | IC 50 | PEGs | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| | DNP-PEG4-DBCO Preparation Products And Raw materials |
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