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2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid

2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid Suppliers list
Company Name: Alchem Pharmtech,Inc.
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Products Intro: Product Name:2-((2S,6R)-6-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-4-yl)acetic acid
CAS:111902-57-9
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-31309
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Products Intro: Product Name:temocapril
CAS:111902-57-9
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Products Intro: Product Name:2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid
CAS:111902-57-9
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Products Intro: Product Name:Temocapril
CAS:111902-57-9
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Products Intro: Product Name:Temocapil
CAS:111902-57-9
Purity:97.8% Package:2mg;40USD|10mg;50USD|25mg;90USD Remarks:REAGENT;FOR LABORATORY USE ONLY

2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid manufacturers

  • Temocapil
  • Temocapil pictures
  • $42.00
  • 2026-06-02
  • CAS:111902-57-9
  • Purity: 97.80%
  • Supply Ability: 10g
  • Temocapril
  • Temocapril pictures
  • 2020-05-09
  • CAS:111902-57-9
  • Min. Order: 1KG
  • Purity: 99.0%
  • Supply Ability: 600 MT
2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid Basic information
Product Name:2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid
Synonyms:(+)-[(2s,6r)-6-[[(s)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid;2-[(2s)-6-[[(1s)-1-ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid;TEMOCAPRIL DISCONTINUED SEE T017301;Temocapil;(2S,6R)-6-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic Aci;1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, (2S,6R)- (9CI);1,4-Thiazepine-4(5H)-acetic acid, 6-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, [2S-[2a,6b(R*)]]-;2-((2S,6R)-6-((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-ylamino)-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-4-yl)aceticacid
CAS:111902-57-9
MF:C23H28N2O5S2
MW:476.61
EINECS:
Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:111902-57-9.mol
2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid Structure
2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid Chemical Properties
Melting point 1680C
alpha 23 +40° (c = 1.1 in DMF)
Boiling point 717.4±60.0 °C(Predicted)
density 1.33±0.1 g/cm3(Predicted)
storage temp. 2-8°C
pka3.73±0.10(Predicted)
form Powder
color Crystalline
CAS DataBase Reference111902-57-9(CAS DataBase Reference)
Safety Information
MSDS Information
2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid Usage And Synthesis
Chemical PropertiesCrystalline Powder
UsesAngiotensin-converting enzyme (ACE) inhibitor. Hydrolyzed in vivo to the active diacid metabolite.
DefinitionChEBI: Temocapril is a dipeptide.
in vivo

Temocapril (10 mg/kg; p.o.; 21 d) enhances cardiomyocyte thioredoxin expression and ameliorates autoimmune myocarditis[3].
Temocapril (30 mg/kg; p.o.; daily; for 4 weeks) suppresses Angiotensin I-induced hypertension, plasma and renal ACE activity, but fails to reduce the level of Ang II in the kidney[4].

Animal Model:Experimental autoimmune myocarditis (EAM) rat model[3]
Dosage:10 mg/kg
Administration:Oral gavage; administration by water; 21 days
Result:Ameliorated EAM and prevented cellular proteins from oxidation.
Enhanced cardiomyocyte redox regulatory protein TRX expression.
Animal Model:Male Sprague Dawley rats[4]
Dosage:30 mg/kg
Administration:Oral gavage, daily, for 4 weeks
Result:Suppressed the blood pressure elevation induced by Ang I.
2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid Preparation Products And Raw materials
Tag:2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid(111902-57-9) Related Product Information
CHLORTALIDONE Butenafine hydrochloride Thiophene NICKEL AND VANADIUM IN RESIDUAL FUEL OIL (2S,6R)-6-Amino-2-(2-thienyl)-1,4-thiazepan-5-one Temocaprilat 1-(2'-THIENYL)ETHYLMERCAPTAN 2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid Temocapril hydrochloride L-Homophenylalanine ethyl ester L-β-Homophenylalanine, HPLC 98% 2-Thienylmethanethiol TEMOCAPRIL-D5 (2S,6R)-6-[[1(s)-Ethoxycarbonyl-3-phenylpropyl]amino]-5-oxo-(2-thienyl)perhydro-1,4-thiazepine