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| | 2 6-DICHLORO-4-NITROPYRIDINE 97 Basic information |
| | 2 6-DICHLORO-4-NITROPYRIDINE 97 Chemical Properties |
| Melting point | 94-98 °C | | Boiling point | 282.9±35.0 °C(Predicted) | | density | 1.629±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | -5.10±0.10(Predicted) | | form | Gold to faint brown/tan, tiny crystalline flakes | | Appearance | Off-white to light yellow Solid | | InChI | InChI=1S/C5H2Cl2N2O2/c6-4-1-3(9(10)11)2-5(7)8-4/h1-2H | | InChIKey | BZYQSSVTQJTUDD-UHFFFAOYSA-N | | SMILES | C1(Cl)=NC(Cl)=CC([N+]([O-])=O)=C1 |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-37/38-41-43-36/37/38 | | Safety Statements | 26-39-36/37/39 | | WGK Germany | 3 | | HS Code | 2933399990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
Skin Sens. 1
STOT SE 3 |
| | 2 6-DICHLORO-4-NITROPYRIDINE 97 Usage And Synthesis |
| Uses | 2,6-Dichloro-4-nitropyridine (cas# 25194-01-8) is a compound useful in organic synthesis. | | Synthesis Reference(s) | Synthetic Communications, 18, p. 659, 1988 DOI: 10.1080/00397918808077351 | | Synthesis | The general procedure for the synthesis of 2,6-dichloro-4-nitropyridine from 2,6-dichloropyridine-N-oxide was as follows: 2,6-dichloropyridine-N-oxide (12.8 g, 78 mmol) was added to a mixed solution consisting of 95% concentrated nitric acid (21 mL) and 98% concentrated sulfuric acid (50 mL). The reaction was stirred at 148 °C for 1 h. The temperature was subsequently raised to 156 °C until no more nitrogen dioxide gas was released. After completion of the reaction, the reaction solution was cooled to room temperature and slowly poured into 150 g of ice water. The pH of the mixture was adjusted to 6 with ammonia, at which point a solid product precipitated. The solid was collected by filtration and the resulting crude product was recrystallized with petroleum ether to give 10 g of yellow solid product in 66.4% yield. | | References | [1] Patent: US2012/289497, 2012, A1. Location in patent: Page/Page column 51-52
[2] Patent: EP2524917, 2012, A1. Location in patent: Page/Page column 58-59
[3] Organic Letters, 2004, vol. 6, # 5, p. 659 - 662
[4] Nucleosides, Nucleotides and Nucleic Acids, 2003, vol. 22, # 12, p. 2133 - 2144 |
| | 2 6-DICHLORO-4-NITROPYRIDINE 97 Preparation Products And Raw materials |
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