| Company Name: |
ForeChem (Nantong) Technology Co.,Ltd.
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| Tel: |
513-85982855 18921614129 |
| Email: |
sales@xianxingpharm.com |
| Products Intro: |
Product Name:(S)-1-Cbz-4-Boc-2-(cyanomethyl)piperazine
CAS:2158302-00-0
Purity:98% Package:1g;10g;100g;1kg
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| | 1-Benzyl 4-(tert-butyl) (S)-2-(cyanomethyl)piperazine-1,4-dicarboxylate Basic information |
| Product Name: | 1-Benzyl 4-(tert-butyl) (S)-2-(cyanomethyl)piperazine-1,4-dicarboxylate | | Synonyms: | 1,4-Piperazinedicarboxylic acid, 2-(cyanomethyl)-, 4-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2S)-;2-Cyanomethyl-piperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester;(S)-2-(4-Boc-1-Cbz-2-piperazinyl)acetonitrile;O1-benzyl O4-tert-butyl (2S)-2-(cyanomethyl)piperazine-1,4-dicarboxylate;(S)-1-Cbz-4-Boc-2-(cyanomethyl)piperazine | | CAS: | 2158302-00-0 | | MF: | C19H25N3O4 | | MW: | 359.42 | | EINECS: | | | Product Categories: | | | Mol File: | 2158302-00-0.mol |  |
| | 1-Benzyl 4-(tert-butyl) (S)-2-(cyanomethyl)piperazine-1,4-dicarboxylate Chemical Properties |
| storage temp. | Storage temp. 2-8°C | | Appearance | Colorless to light yellow Oil |
| | 1-Benzyl 4-(tert-butyl) (S)-2-(cyanomethyl)piperazine-1,4-dicarboxylate Usage And Synthesis |
| Chemical Properties | White solid | | Synthesis | Dissolve (S)-3-(cyanomethyl)piperazine-1-carboxylic acid tert-butyl ester (2.25g, 10mmol) in 15mL dichloromethane, add N,N-diisopropylethylamine at room temperature (3.87g, 30mmol) was cooled to 0°C, benzyl chloroformate was added dropwise, and reacted at low temperature for 2h. Add 25 mL of water to the reaction solution, extract the aqueous phase with dichloromethane (30 mL×3), combine the organic phases, wash the organic phase with water (20 mL×2), dry with anhydrous sodium sulfate, concentrate, and separate and purify the crude product by silica gel column chromatography (Ethyl acetate/petroleum ether (v/v)=1:20-1:5) to obtain 1-Benzyl 4-(tert-butyl) (S)-2-(cyanomethyl)piperazine-1,4-dicarboxylate (3.1 g, yield: 86%).
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| | 1-Benzyl 4-(tert-butyl) (S)-2-(cyanomethyl)piperazine-1,4-dicarboxylate Preparation Products And Raw materials |
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