- 1-Boc-3-iodoazetidine
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- $1.50
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2026-05-15
- CAS:254454-54-1
- Min. Order: 1g
- Purity: 99.0% Min
- Supply Ability: 100 Tons
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| | 1-Boc-3-iodoazetidine Basic information |
| Product Name: | 1-Boc-3-iodoazetidine | | Synonyms: | 1-BOC-3-IODO-AZETIDINE 98%;3-Iodoazetidine, N-BOC protected;1-N-Boc-3-iodoazetidine;1-Boc-3-iodo-azetidine;1-tert-Butoxycarbonyl-3-iodoazetidine;tert-Butyl 3-iodoazetidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-3-iodoazetidine;3-Iodoazetidine, N-BOC protected 97%;1-(tert-Butoxycarbonyl)-3-iodoazetidine > | | CAS: | 254454-54-1 | | MF: | C8H14INO2 | | MW: | 283.11 | | EINECS: | 674-969-9 | | Product Categories: | Azetidine | | Mol File: | 254454-54-1.mol |  |
| | 1-Boc-3-iodoazetidine Chemical Properties |
| Boiling point | 282.0±33.0 °C(Predicted) | | density | 1.63g/ml | | refractive index | 1.5090 to 1.5130 | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | clear liquid | | pka | -3.39±0.40(Predicted) | | color | Colorless to Brown | | Sensitive | Light Sensitive | | InChI | InChI=1S/C8H14INO2/c1-8(2,3)12-7(11)10-4-6(9)5-10/h6H,4-5H2,1-3H3 | | InChIKey | XPDIKRMPZNLBAC-UHFFFAOYSA-N | | SMILES | N1(C(OC(C)(C)C)=O)CC(I)C1 | | CAS DataBase Reference | 254454-54-1(CAS DataBase Reference) |
| Hazard Codes | Xi,N,T | | Risk Statements | 25-36-50 | | Safety Statements | 26-45 | | RIDADR | UN 3082 9 / PGIII | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29339900 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1
Eye Irrit. 2 |
| | 1-Boc-3-iodoazetidine Usage And Synthesis |
| Chemical Properties | Colorless to red-brown liquid | | Uses | 1-Boc-3-iodoazetidine is used as an organic chemical synthesis intermediate. | | Synthesis | The general procedure for the synthesis of 1-Boc-3-iodoazetidine from N-Boc-3-hydroxyazetidine is as follows:
Step B: Synthesis of tert-butyl 3-iodoazetidine-1-carboxylate. To a solution of tert-butyl 3-hydroxyazetidine-1-carboxylate (3.35 g, 19.3 mmol) in toluene (200 mL) was sequentially added imidazole (3.95 g, 58.0 mmol), triphenylphosphine (10.1 g, 38.7 mmol) and iodine (7.36 g, 29.0 mmol). The reaction mixture was heated at 100 °C for 1 h, subsequently cooled to room temperature and poured into aqueous sodium bicarbonate solution (30 mL). Iodine was added to quench the excess triphenylphosphine until the iodine color in the organic layer disappeared. The organic layer was separated, washed with saturated aqueous sodium thiosulfate and dried over anhydrous sodium sulfate. The crude product was purified by silica gel column chromatography (eluent ratio: hexane/ethyl acetate = 9:1 to 1:1) to afford 1-Boc-3-iodoazetidine (5.42 g, 99% yield) as a clear oil.
MS (ESI) m/z 284 (M + 1)+. | | References | [1] Patent: WO2010/84767, 2010, A1. Location in patent: Page/Page column 47
[2] Patent: WO2006/40182, 2006, A1. Location in patent: Page/Page column 132-133
[3] Patent: WO2008/116831, 2008, A1. Location in patent: Page/Page column 37
[4] Patent: WO2011/140488, 2011, A1. Location in patent: Page/Page column 287; 288
[5] Patent: EP2773638, 2015, B1. Location in patent: Paragraph 0805; 0806 |
| | 1-Boc-3-iodoazetidine Preparation Products And Raw materials |
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