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| | 2,4-Dichloropyridine-3-carboxaldehyde Basic information | | Application |
| Product Name: | 2,4-Dichloropyridine-3-carboxaldehyde | | Synonyms: | 2,4-DICHLOROPYRIDINE-3-CARBOXALDEHYDE;2,4-dichloro-3-pyridine Carboxaldehyde;3-Pyridinecarboxaldehyde,2,4-dichloro;2,4-dichloronicotinaldehyde (en);2,4-Dichloropyridine-3-carboxaldehyde 97%;2,4-Dichloro-pyridin-3-carbaldehyde;EOS-61543;2,4-Dichloro-3-formylpyridine | | CAS: | 134031-24-6 | | MF: | C6H3Cl2NO | | MW: | 176 | | EINECS: | | | Product Categories: | Pyridines | | Mol File: | 134031-24-6.mol |  |
| | 2,4-Dichloropyridine-3-carboxaldehyde Chemical Properties |
| Melting point | 72-75℃ | | Boiling point | 261.8±35.0 °C(Predicted) | | density | 1.488±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | form | powder to crystal | | pka | -1.17±0.10(Predicted) | | color | White to Orange to Green | | Sensitive | Air Sensitive | | InChI | InChI=1S/C6H3Cl2NO/c7-5-1-2-9-6(8)4(5)3-10/h1-3H | | InChIKey | GWBHJHIZHNTJLA-UHFFFAOYSA-N | | SMILES | C1(Cl)=NC=CC(Cl)=C1C=O |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38 | | Safety Statements | 26 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 2933399990 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2,4-Dichloropyridine-3-carboxaldehyde Usage And Synthesis |
| Application | 2,4-Dichloronicotinaldehyde, also known as 2,4-dichloronicotinaldehyde, can be obtained by reacting 2,4-dichloropyridine with a strong base to obtain (2,4-4-dichloro-3-pyridyl)lithium, and then reacting it with DMF. | | Chemical Properties | Yellow solid | | Synthesis | To a solution of 2,4-dichloropyridine (2 g, 13.51 mmol) in tetrahydrofuran (20 mL) at -78° C added LDA in THF/heptane/ethylbenzene (2M, 8.11 mL, 16.22 mmol) and the solution was stirred for 30 min. DMF (10.46 mL, 135 mmol) was added and the solution was stirred for 1 h and then warmed RT. The reaction mixture was quenched with saturated NH4Cl solution and diluted with ethyl acetate (50 mL). The organic layer was washed with saturated NaHCO3 (2*10 mL), water (20 mL), dried over Na2SO4, and concentrated under reduced pressure to afford 2,4-dichloronicotinaldehyde (2 g, 11.36 mmol, 84% yield).  | | References | [1] Tetrahedron Letters, 2011, vol. 52, # 4, p. 523 - 525
[2] Organic Process Research and Development, 2018, vol. 22, # 8, p. 978 - 990
[3] Patent: US2013/237555, 2013, A1. Location in patent: Paragraph 0273
[4] Patent: WO2015/38112, 2015, A1. Location in patent: Page/Page column 126
[5] Patent: WO2018/109050, 2018, A1. Location in patent: Paragraph 0286-0297 |
| | 2,4-Dichloropyridine-3-carboxaldehyde Preparation Products And Raw materials |
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