熊去氧膽酸雜質(zhì)24
| 中文名稱 | 熊去氧膽酸雜質(zhì)24 |
|---|---|
| 中文同義詞 | 24-去甲熊去氧膽酸(NOR-UDCA);24-去甲氧基膽酸;化合物24-NORURSODEOXYCHOLIC ACID;熊去氧膽酸雜質(zhì)24;24-去氧膽酸;24-去甲熊去氧膽酸;(R)-3-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-二羥基-10,13-二甲基十六氫-1H-環(huán)戊并[A]菲-17-基]丁酸;24-去甲熊脫氧膽酸 |
| 英文名稱 | 24-norursodeoxycholic acid |
| 英文同義詞 | 24-norursodeoxycholic acid;(3α,5β,7β)-3,7-Dihydroxy-24-norcholan-23-oic Acid;3α,7β-Dihydroxy-24-nor-5β-cholan-23-oic Acid;24-Norursodeoxycholic acid,24Norursodeoxycholic acid,Inhibitor,Norucholic acid,24 Norursodeoxycholic acid,inhibit;24-Norcholan-23-oic acid, 3,7-dihydroxy-, (3α,5β,7β)-;Urosodeoxycholic Acid Impurity 24;(R)-3-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]butanoic Acid;24-Norursodeoxycholic acid, 10 mM in DMSO |
| CAS號 | 99697-24-2 |
| 分子式 | C23H38O4 |
| 分子量 | 378.55 |
| EINECS號 | |
| 相關(guān)類別 | 抑制劑;膽酸系列;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids |
| Mol文件 | 99697-24-2.mol |
| 結(jié)構(gòu)式 |  |
熊去氧膽酸雜質(zhì)24 性質(zhì)
| 熔點 | 117 - 123°C |
|---|---|
| 沸點 | 536.7±25.0 °C(Predicted) |
| 密度 | 1.142±0.06 g/cm3(Predicted) |
| 儲存條件 | Refrigerator |
| 溶解度 | DMSO（微溶）、乙醇（微溶）、甲醇（微溶） |
| 酸度系數(shù)(pKa) | 4.71±0.10(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 灰白色至淺黃色 |
| InChIKey | QYYDXDSPYPOWRO-JHMCBHKWSA-N |
| SMILES | O[C@@H]1[C@@H]2[C@@H]([C@@]4([C@H](C1)C[C@@H](CC4)O)C)CC[C@]3([C@H]2CC[C@@H]3[C@@H](CC(=O)O)C)C |
24-norursodeoxycholic acid (norUDCA) 是側(cè)鏈縮短的 UDCA 的 C23 同系物，具有有效的抗膽汁淤積，抗炎和抗纖維化特性。
24-norursodeoxycholic acid (norUDCA) is a side chain-shortened C23 homologue of UDCA and is previously shown to be highly effective in preclinical mouse models of cholestatic and fibrotic liver diseases. 24-norursodeoxycholic acid significantly reduces serum alkaline phosphatase (ALP) levels in a dose-dependent fashion. 24-norursodeoxycholic acid also significantly reduces γ-GT, ALT, and AST serum levels.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存儲類別 | 11 - 可燃固體 |
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-101737R | 熊去氧膽酸雜質(zhì)24 24-Norursodeoxycholic acid (Standard) | 99697-24-2 | 5 mg | 1750元 |
| 2026/06/05 | HY-101737 | 熊去氧膽酸雜質(zhì)24 24-Norursodeoxycholic acid | 99697-24-2 | 1mg | 280元 |
上游原料