他扎司特
| 中文名稱 | 他扎司特 |
|---|---|
| 中文同義詞 | 他扎司特;丁基-3'-(1H-四唑-5-基)苯酰羧酸;塔贊司特;化合物 T17001 |
| 英文名稱 | TAZANOLAST |
| 英文同義詞 | Butyl 3'-(1H-tetrazol-5-y1)oxanilate;Tazalest;Tazanol;TO-188;TAZANOLAST;N-[3-(1H-Tetrazol-5-yl)phenyl]oxamidic acid butyl ester;Oxo[[3-(1H-tetrazol-5-yl)phenyl]amino]acetic acid butyl ester;WP-833 |
| CAS號(hào) | 82989-25-1 |
| 分子式 | C13H15N5O3 |
| 分子量 | 289.29 |
| EINECS號(hào) | |
| 相關(guān)類別 | 科研試劑;呼吸系統(tǒng)用藥;平喘藥;藥物;平喘藥物 |
| Mol文件 | 82989-25-1.mol |
| 結(jié)構(gòu)式 | ![]() |
他扎司特 性質(zhì)
| 密度 | 1.343 |
|---|---|
| 儲(chǔ)存條件 | 2-8°C |
| 溶解度 | 溶于二甲基亞砜 |
| 酸度系數(shù)(pKa) | 4.06±0.10(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
Tazanolast, an orally active mast-cell-stabilizing drug, which has been shown to suppress passive cutaneous anaphylaxis, Schultz-Dale reaction in isolated tracheal muscle, and experimental asthma without antagonistic actions upon histamine- and leukotriene-D4-induced contraction, IgE-mediated or compound 48/80-induced histamine release from mast cells and lung fragments, compound 48/80-induced Ca 2+ uptake into mast cells from extracellular medium, compound 48/80-induced translocation of protein kinase C from the cytosol to the membrane fraction of mast cells, and inositol trisphosphate production without directly inhibiting phospholipase C in mast cells.
Tazanolast administered before ozone exposure at doses of 30, 100, or 300 mg/kg inhibits ozone-induced airway hyperresponsiveness in a dose-dependent manner. Tazanolast administered after ozone exposure does not inhibit the airway hyperresponsiveness. Tazanolast does not significantly change the cell distribution of bronchoalveolar lavage (BAL) cells at 2 h after the exposure. Tazanolast significantly inhibits ozone-induced airway hyperresponsiveness in guinea pigs.
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-101810 | 他扎司特 Tazanolast | 82989-25-1 | 5 mg | 850元 |
| 2026/06/05 | HY-101810 | 他扎司特 Tazanolast | 82989-25-1 | 10 mM * 1 mLin DMSO | 935元 |
