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hepsulfam

hepsulfam

中文名稱hepsulfam
中文同義詞化合物 T15472;庚烷-1,7-二基 雙(氨基磺酸酯);化合物 HEPSULFAM
英文名稱hepsulfam
英文同義詞hepsulfam;Bis(amidosulfuric acid)1,7-heptanediyl ester;Bissulfamideoic acid 1,7-heptanediyl ester;NSC-329680;Sulfamic acid, S,S'-1,7-heptanediyl ester;ZINC01574758;NCI 329680;7-sulfamoyloxyheptyl sulfamate
CAS號96892-57-8
分子式C7H18N2O6S2
分子量290.36
EINECS號
相關(guān)類別
Mol文件96892-57-8.mol
結(jié)構(gòu)式hepsulfam 結(jié)構(gòu)式

hepsulfam 性質(zhì)

熔點94-95 °C
沸點478.2±55.0 °C(Predicted)
密度1.407±0.06 g/cm3(Predicted)
儲存條件Store at -20°C
溶解度溶于二甲基亞砜
形態(tài)固體
酸度系數(shù)(pKa)9.10±0.70(Predicted)
顏色白色至米白色

hepsulfam 用途與合成方法

Hepsulfam (NCI 329680; ZINC01574758) 是抗癌試劑,具有優(yōu)異的抗白血病活性,在不同腫瘤中的中位 IC50 值為0.91 μg/mL。

IC50: 0.91 μg/mL (Tumors)

At a concentration of 1.0 μg/mL, hepsulfam is active in eight of 37 tumors (22%) in the clonogenic assay. Hepsulfam demonstrates a clear in vitro toxicity to human bone marrow cells (CFU-GM) from healthy donors. Evaluation of equitoxic concentrations in vitro reveals a higher activity of hepsulfam, especially in non-small cell lung cancer. Hepsulfam is more toxic to L1210 leukemia cells than is busulfan, its structural homologue . Consistent with the difference in toxicity, hepsulfam induces DNA interstrand cross-links in L1210 mouse leukemia cells, whereas busulfan does not. Hepsulfam is more cytotoxic to two human leukemia cell lines (111-60 and K562) and to two human colon carcinoma cell lines (BE and HT-29) than is busulfan. As in 11210 cells, hepsulfam induces a higher level of DNA interstrand cross-links than busulfan. Hepsulfam is also more cytotoxic to the human leukemia cell lines when the concentrations are reduced 10-fold and the duration of drug exposure is increased to 12 h.

Hepsulfam demonstrates superior in vivo activity in a large cell lung cancer xenograft and a gastric carcinoma model. The preclinical activity of hepsulfam suggests a possible role of this compound in the treatment of solid human malignancies. However, the increased bone marrow toxicity of hepsulfam as compared with busulfan might be critical for further clinical application.

安全信息

MSDS信息

更新日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2026/06/05HY-U00095hepsulfam
Hepsulfam
96892-57-81mg400元
2026/06/05HY-U00095hepsulfam
Hepsulfam
96892-57-85mg800元

hepsulfam 上下游產(chǎn)品信息

"hepsulfam"相關(guān)產(chǎn)品信息
帕利哌酮雜質(zhì)15 氨基磺酸十二酯 帕潘立酮雜質(zhì)14
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