1-HYDROXYPIPERIDINE manufacturers
- 1-HYDROXYPIPERIDINE
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- $9.80
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2020-01-09
- CAS:4801-58-5
- Min. Order: 1g
- Purity: ≥99%
- Supply Ability: 100kg
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| | 1-HYDROXYPIPERIDINE Basic information |
| | 1-HYDROXYPIPERIDINE Chemical Properties |
| Melting point | 37-39 °C | | Boiling point | 146-148℃ (1 Torr) | | density | 0.9903 (rough estimate) | | refractive index | 1.4550 (estimate) | | Fp | 78 °C | | storage temp. | 2-8°C | | pka | 14.19±0.20(Predicted) | | form | low melting solid | | color | White | | BRN | 102726 | | InChI | 1S/C5H11NO/c7-6-4-2-1-3-5-6/h7H,1-5H2 | | InChIKey | LKPFBGKZCCBZDK-UHFFFAOYSA-N | | SMILES | ON1CCCCC1 | | EPA Substance Registry System | Piperidine, 1-hydroxy- (4801-58-5) |
| WGK Germany | 3 | | RTECS | TN6829550 | | F | 3-10 | | TSCA | TSCA listed | | HS Code | 2933399990 | | Storage Class | 11 - Combustible Solids |
| | 1-HYDROXYPIPERIDINE Usage And Synthesis |
| Chemical Properties | Soluble in water, organic solvents, aqueous acids, and bases. | | Uses | Base for Fmoc-based solid phase peptide synthesis1Light stabilizing agent2 | | Uses | Base for Fmoc-based solid phase peptide synthesis
Light stabilizing agent | | Synthesis Reference(s) | The Journal of Organic Chemistry, 53, p. 5856, 1988 DOI: 10.1021/jo00260a012 | | Synthesis | General procedure for the synthesis of N-hydroxypiperidine from hexahydropyridine: hexahydropyridine (5 mmol) and ChPS (5.5 mmol) were added to a round-bottomed flask under nitrogen protection, and the reaction was stirred for 1 hr at 60 °C. After completion of the reaction, the mixture was dissolved in water (5 mL) and the product was extracted with dichloromethane or ethyl acetate (5 mL each time, 3 times). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the target product N-hydroxypiperidine. | | References | [1] Synlett, 2017, vol. 28, # 17, p. 2315 - 2319
[2] Tetrahedron Letters, 2001, vol. 42, # 20, p. 3419 - 3422
[3] Justus Liebigs Annalen der Chemie, 1948, vol. 559, p. 1,22, 23
[4] Chemische Berichte, 1951, vol. 84, p. 690,698
[5] Chemische Berichte, 1892, vol. 25, p. 2782 |
| | 1-HYDROXYPIPERIDINE Preparation Products And Raw materials |
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