| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:13,14-dihydro-15-keto Prostaglandin D2-d4
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Cayman Chemical Company
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| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:13,14-dihydro-15-keto Prostaglandin D2-d4
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| Company Name: |
Santa Cruz Biotechnology Inc
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| Tel: |
021-60936350 |
| Email: |
scbt@scbt.com |
| Products Intro: |
Product Name:13,14-dihydro-15-keto Prostaglandin D2-d4
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| Company Name: |
Neobioscience Co., Ltd.
|
| Tel: |
4006-800-892 |
| Email: |
info@neobioscience.com |
| Products Intro: |
Product Name:13,14-dihydro-15-keto Prostaglandin D2-d4
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| | 13,14-dihydro-15-keto Prostaglandin D2-d4 Basic information |
| | 13,14-dihydro-15-keto Prostaglandin D2-d4 Chemical Properties |
| solubility | DMF: 50 mg/ml
DMSO: 30 mg/ml
Ethanol: 50 mg/mlPBS (pH 7.2): 2 mg/ml |
| | 13,14-dihydro-15-keto Prostaglandin D2-d4 Usage And Synthesis |
| Description | 13,14-dihydro-15-keto Prostaglandin D2-d4 (13,14-dihydro-15-keto PGD2-d4) is intended for use as an internal standard for the quantification of 13,14-dihydro-15-keto PGD2 (Item No. 12610) by GC- or LC-mass spectrometry. 13,14-dihydro-15-keto PGD2 is a metabolite of PGD2 which is formed through the 15-hydroxy PGDH pathway. 13,14-dihydro-15-keto PGD2 was recently identified as a selective agonist for the CRTH2/DP2 receptor.1 It also inhibits ion flux in a canine colonic mucosa preparation.2 In humans, 13,14-dihydro-15-keto PGD2 is further metabolized to give 11β-hydroxy compounds which have also undergone β-oxidation of one or both side chains. Virtually no 13,14-dihydro-15-keto PGD2 survives intact in the urine.3,4WARNING This product is not for human or veterinary use. | | References | [1] P K RANGACHARI P A B. Biological activity of metabolites of PGD2 on canine proximal colon.[J]. American Journal of Physiology, 1993, 264 5 Pt 1: G886-94. DOI: 10.1152/ajpgi.1993.264.5.g886
[2] H. HIRAI. Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2[J]. The Tokushima journal of experimental medicine, 2001, 1 1: 255-262. DOI: 10.1084/jem.193.2.255
[3] T E LISTON L J R. Metabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteer.[J]. The Journal of Biological Chemistry, 1985, 260 24: 13172-13180.
[4] JASON D. MORROW. Quantification of the major urinary metabolite of prostaglandin D2 by a stable isotope dilution mass spectrometric assay[J]. Analytical biochemistry, 1991, 193 1: Pages 142-148. DOI: 10.1016/0003-2697(91)90054-w |
| | 13,14-dihydro-15-keto Prostaglandin D2-d4 Preparation Products And Raw materials |
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