(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride
生物活性體內(nèi)研究 用途與合成方法 MSDS (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride價(jià)格(試劑級(jí)) 上下游產(chǎn)品信息
| 中文名稱 | (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride |
|---|---|
| 中文同義詞 | PF-04859989 鹽酸鹽;化合物PF-04859989;(S)-3-氨基-1-羥基-3,4-二氫喹啉-2(1H)-酮鹽酸;化合物PF-04859989,10 MM DMSO 溶液 |
| 英文名稱 | (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride |
| 英文同義詞 | (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride;(3S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one;L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride;PF04859989 hydrochloride;PF-04859989 hydrochloride;PF-4859989 hydrochloride;PF 04859989 hydrochloride - L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride;PF-04859989 hydrochloride >=98% (HPLC) |
| CAS號(hào) | 177943-33-8 |
| 分子式 | C9H11ClN2O2 |
| 分子量 | 214.64884 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 177943-33-8.mol |
| 結(jié)構(gòu)式 |  |
(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride 性質(zhì)
| 儲(chǔ)存條件 | room temp |
|---|---|
| 溶解度 | 在水中的溶解度為20mg/mL，澄清 |
| 形態(tài) | 粉末 |
| 顏色 | 白色至米色 |
| 水溶解性 | Water: 22 mg/ml |
| InChI | 1S/C9H10N2O2.ClH/c10-7-5-6-3-1-2-4-8(6)11(13)9(7)12;/h1-4,7,13H,5,10H2;1H/t7-;/m0./s1 |
| InChIKey | WZOBDOKCHIUXAY-FJXQXJEOSA-N |
| SMILES | N[C@H]1CC2=CC=CC=C2N(O)C1=O.Cl |
PF-04859989 hydrochloride 是一種可透過(guò)血腦屏障的，不可逆的犬尿氨酸轉(zhuǎn)氨酶 KAT II 抑制劑，對(duì) hKATⅡ 和 rKATⅡ 的 IC50 分別為 23 和 263 nM。PF-04859989 hydrochloride 對(duì) KATⅡ 的選擇性高于人 KATⅠ、KATⅢ 和 KATⅣ (IC50 分別為22、11和 >50 μM)。
In vivo pharmacokinetic and efficacy studies in rat show that PF-04859989 is a brain-penetrant, irreversible inhibitor and is capable of reducing brain kynurenic acid by 50% at a dose of 10 mg/kg (sc).
Rats receiving PF-04859989 (5 mg/kg; i.p.) exhibited a significantly lower number of spontaneously active DA neurons pertrack.
| Animal Model: | Male Sprague-Dawley rats |
| Dosage: | 5 mg/kg |
| Administration: | I.p. |
| Result: | Exhibited a significantly lower number of spontaneously active dopamine (DA) neurons pertrack compared to controls. |
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存儲(chǔ)類別 | 11 - 可燃固體 |
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-116451 | PF-04859989 hydrochloride | 177943-33-8 | 1 mg | 300元 |
| 2026/06/05 | HY-116451 | (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride PF-04859989 hydrochloride | 177943-33-8 | 5mg | 600元 |