PR104

PR104 Suppliers list
Company Name: Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel: +86-057181025280; +8617767106207
Email: sales@molcore.com
Products Intro: Product Name:PR-104/104A
CAS:851627-62-8
Purity:NLT 98% Remarks:MC457884
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:PR-104
CAS:851627-62-8
Package:100mg;2500USD|50mg;1710USD|25mg;1310USD
Company Name: BOC Sciences  
Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Products Intro: Product Name:PR-104
CAS:851627-62-8
Purity:>=97% Remarks:Reach out to us for more information about custom solutions.
Company Name: SPIRO PHARMA  
Tel:
Email: eric_feng1954@126.com
Products Intro: Product Name:PR104
CAS:851627-62-8
Purity:95% -98%HPLC Package:1GR;10GR;50GR;100GR;250GR;500GR;1KG;5KG;10KG;100KG
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310 15002144251
Email: marketing@tsbiochem.com
Products Intro: Product Name:PR-104
CAS:851627-62-8
Package:2mg/RMB 3420;25mg/RMB 10600;50mg/RMB 13800

PR104 manufacturers

  • PR-104
  • PR-104 pictures
  • $2500.00
  • 2026-04-22
  • CAS:851627-62-8
  • Purity:
  • Supply Ability: 10g
PR104 Basic information
Product Name:PR104
Synonyms:PR-104/104A;PR104;2-((2-Bromoethyl)(2,4-dinitro-6-((2-(phosphonooxy)ethyl)carbamoyl)phenyl)amino)ethyl methanesulfonate;GZSOKPMDWVRVMG-UHFFFAOYSA-N;2-[N-(2-bromoethyl)-2,4-dinitro-6-(2-phosphonooxyethylcarbamoyl)anilino]ethyl methanesulfonate;PR 104;PR104;Benzamide, 2-[(2-bromoethyl)[2-[(methylsulfonyl)oxy]ethyl]amino]-3,5-dinitro-N-[2-(phosphonooxy)ethyl]-
CAS:851627-62-8
MF:C14H20BrN4O12PS
MW:579.27
EINECS:
Product Categories:
Mol File:851627-62-8.mol
PR104 Structure
PR104 Chemical Properties
storage temp. 4°C, away from moisture and light
form Solid
color White to yellow
Safety Information
MSDS Information
PR104 Usage And Synthesis
UsesPR-104 is a selective hypoxia-activated DNA cross-linking agent and can be used for the research of multiple tumor xenograft models. PR-104, as a nitrogen mustard pre-proagent, is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A[1].
in vivo

PR-104 (0.56 mmol/kg; i.v. or i.p.; 0~2 hours) makes the plasma area under the curve. PR-104 (0.23 mmol/kg; i.p.; 100 days) shows antitumor activity[1].

Animal Model:CD-1nu/nu mice
Dosage:0.56 mmol/kg (Pharmacokinetics Analysis)
Administration:I.v. or i.p.
Result:The plasma area under the curve.
Animal Model:CD1-Foxn1nu mice
Dosage:0.23 mmol/kg
Administration:I.p.
Result:Showed antitumor activity.
References[1] Patterson AV, et al. Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104. Clin Cancer Res. 2007;13(13):3922-3932. DOI:10.1158/1078-0432.CCR-07-0478
PR104 Preparation Products And Raw materials
Tag:PR104(851627-62-8) Related Product Information