N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide manufacturers
- FK962
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- $51.00
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2026-05-11
- CAS:283167-06-6
- Purity: 99.89%
- Supply Ability: 10g
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| | N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide Basic information |
| Product Name: | N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide | | Synonyms: | N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide;Benzamide, N-(1-acetyl-4-piperidinyl)-4-fluoro-;N-(1-acetylpiperidin-4-yl)-4-fluorobenzamide;FK962;Alzheimer,somatostatin,FK-962,FK 962,inhibit,FK962,Inhibitor,cognitive;FK962, 10 mM in DMSO;FK962 ，S0535 | | CAS: | 283167-06-6 | | MF: | C14H17FN2O2 | | MW: | 264.3 | | EINECS: | | | Product Categories: | | | Mol File: | 283167-06-6.mol |  |
| | N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide Chemical Properties |
| storage temp. | Sealed in dry,Room Temperature | | solubility | Soluble in DMSO | | form | Solid | | color | White to off-white |
| | N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide Usage And Synthesis |
| Uses | FK962 is an enhancer of somatostatin release, exerts cognitive-enhancing actions. Anti-dementia properties[1]. | | in vivo | FK962 (0.1, 0.3 or 1.0 mg/kg; i.p.) and Donepezil (a single dose of 1 mg/kg) act synergistically to improve cognition in rats: as an add-on therapy for Alzheimer's disease[2]. | Animal Model: | Male Lister Hooded rats, weighing approximately 270-300[2] | | Dosage: | 0.1, 0.3 or 1.0 mg/kg; Donepezil was given as a single dose of 1 mg/kg | | Administration: | Administered i.p. | | Result: | Resulted in minimal cognition enhancement when given separately. Combination showed a significantly greater effect on cognition. |
| | References | [1] Tokita K, et al. FK962, a novel enhancer of somatostatin release, exerts cognitive-enhancing actions in rats. Eur J Pharmacol. 2005 Dec 19;527(1-3):111-20. DOI:10.1016/j.ejphar.2005.10.022
[2] McCarthy AD, et al. FK962 and donepezil act synergistically to improve cognition in rats: potential as an add-on therapy for Alzheimer's disease. Pharmacol Biochem Behav. 2011 Mar;98(1):76-80. DOI:10.1016/j.pbb.2010.11.019 |
| | N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide Preparation Products And Raw materials |
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