CTEP Derivative manufacturers
- Basimglurant
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- $68.00
-
2026-04-20
- CAS:802906-73-6
- Purity: 99.38%
- Supply Ability: 10g
- Basimglurant
-
- $68.00
-
2026-04-20
- CAS:802906-73-6
- Purity: 99.38%
- Supply Ability: 10g
- CTEP Derivative
-
- $1.00
-
2019-12-24
- CAS:802906-73-6
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 20kg
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| | CTEP Derivative Basic information |
| Product Name: | CTEP Derivative | | Synonyms: | CTEP Derivative;RG 7090;RG7090;RG-7090;2-Chloro-4-((1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-yl)ethynyl)pyridine;RG7090(Basimglurant);2-Chloro-4-[2-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-yl]ethynyl]pyridine;Ro 4917523 | | CAS: | 802906-73-6 | | MF: | C18H13ClFN3 | | MW: | 325.77 | | EINECS: | | | Product Categories: | | | Mol File: | 802906-73-6.mol |  |
| | CTEP Derivative Chemical Properties |
| Melting point | 132 - 135°C | | Boiling point | 526.6±60.0 °C(Predicted) | | density | 1.21±0.1 g/cm3(Predicted) | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 5.27±0.70(Predicted) | | form | Solid | | color | Pale Brown to Light Brown | | Stability: | Hygroscopic, Moisture Sensitive | | InChI | InChI=1S/C18H13ClFN3/c1-12-17(8-3-14-9-10-21-18(19)11-14)22-13(2)23(12)16-6-4-15(20)5-7-16/h4-7,9-11H,1-2H3 | | InChIKey | UPZWINBEAHDTLA-UHFFFAOYSA-N | | SMILES | C1(Cl)=NC=CC(C#CC2=C(C)N(C3=CC=C(F)C=C3)C(C)=N2)=C1 |
| | CTEP Derivative Usage And Synthesis |
| Uses | Basimglurant is a potent, selective and orally available mGlu5 negative allosteric modulator for the treatment of mood disorders. | | in vivo | Basimglurant (RG7090) is a potent, selective, and safe mGlu5 inhibitor with good oral bioavailability and long half-life supportive of once-daily administration, good brain penetration, and high in vivo potency. It has antidepressant properties which are corroborated by its functional magnetic imaging (fMRI) profile, as well as anxiolytic-like and antinociceptive features[1]. It is currently in phase II clinical studies for the treatment of depression and fragile X syndrome. In the Vogel conflict drinking test, Basimglurant dose dependently increases the drinking time. The total plasma exposure of efficacious doses of Basimglurant (RG7090) ranges from 5 ng/mL (0.03 mg/kg) to 37 ng/mL (0.3 mg/kg)[2]. | | IC 50 | mGlu5 Receptor: 1.1 nM (Kd) |
| | CTEP Derivative Preparation Products And Raw materials |
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