1305115-80-3
| 中文名稱 | 1305115-80-3 |
|---|---|
| 中文同義詞 | 化合物 T12422;(R)-3-((4-(噻唑-2-基甲基)嗎啉-2-基)甲基)-5-(三氟甲基)-3H-[1,2,3]三唑[4,5-D]嘧啶-7-胺;3-[[(2R)-4-(2-噻唑基甲基)-2-嗎啉基]甲基]-5-(三氟甲基)-3H-1,2,3-三唑并[4,5-D]嘧啶-7-胺;化合物 PF-04957325;化合物 PF-04957325,10 MM DMSO 溶液;PF-04957325 抑制劑;PF-04957325 抑制劑 |
| 英文名稱 | PF 4957325 |
| 英文同義詞 | PF 04957325;PF 4957325;PF-04957325;3-[[(2R)-4-(1,3-thiazol-2-ylmethyl)morpholin-2-yl]methyl]-5-(trifluoromethyl)triazolo[4,5-d]pyrimidin-7-amine;3-{[(2R)-4-(1,3-thiazol-2-ylmethyl)morpholin-2-yl]methyl}-5-(trifluoromethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine;PF04957325; PF4957325;3H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine, 3-[[(2R)-4-(2-thiazolylmethyl)-2-morpholinyl]methyl]-5-(trifluoromethyl)-;PF04957325,PF 04957325 |
| CAS號(hào) | 1305115-80-3 |
| 分子式 | C14H15F3N8OS |
| 分子量 | 400.38 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 1305115-80-3.mol |
| 結(jié)構(gòu)式 |  |
1305115-80-3 性質(zhì)
| 密度 | 1.81±0.1 g/cm3(Predicted) |
|---|---|
| 儲(chǔ)存條件 | Store at -20°C |
| 溶解度 | 二甲基亞砜：9.9 mg/ml（24.73 mM） |
| 酸度系數(shù)(pKa) | 4.51±0.10(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
IC50: 0.7 nM (PDE8A), less than 0.3 nM (PDE8B)
PF-04957325 is over two orders of magnitude less efficient than PICL in suppressing polyclonal Teff cell proliferation, and shows no effect on cytokine gene expression in these cells, despite its robust effect on T cell adhesion. PF-04957325 is a selective PDE8 inhibitor and inhibits breast cancer cell migration. PF-04957325 greatly potentiates steroidogenesis in WT adrenal cells. PF-04957325 shows a reported IC 50 of 0.7 nM against PDE8A, 0.2 nM against PDE8B, and > 1.5 μM against all other PDE isoforms. PF-04957325 treatment of WT Leydig cells or MA10 cells increases steroid production but has no effect in PDE8A (-/-)/B(-/-) double-knockout cells, confirming the selectivity of the drug. Moreover, under basal conditions, cotreatment with PF-04957325 plus rolipram, a PDE4-selective inhibitor, synergistically potentiates steroid production.
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-15426 | 1305115-80-3 PF-04957325 | 1305115-80-3 | 1mg | 1500元 |
| 2025/12/22 | HY-15426 | 1305115-80-3 PF-04957325 | 1305115-80-3 | 10mM * 1mLin DMSO | 2643元 |