4-(DIMETHYLAMINO)-N-[6-(HYDROXYAMINO)-6-OXOHEXYL]-BENZAMIDE

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Products Intro: Product Name:CAY10398
CAS:193551-00-7
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Products Intro: Product Name:4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide
CAS:193551-00-7
Purity:>98% Package:$30.9/1mg;$136.9/5mg;$244.9/10mg;$532.9/25mg;$1140.9/60mg;Bulk package Remarks:>98%
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Products Intro: Product Name:4-(diMethylaMino)-N-[6-(hydroxyaMino)-6-oxohexyl]-benzaMide
Purity:>98%
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Products Intro: Product Name:CAY10398
CAS:193551-00-7
Purity:98% Package:1G;10G;100G
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Products Intro: Product Name:CAY10398
CAS:193551-00-7
Purity:>98% Package:1mg;10mg;50mg;100mg;
4-(DIMETHYLAMINO)-N-[6-(HYDROXYAMINO)-6-OXOHEXYL]-BENZAMIDE Basic information
Product Name:4-(DIMETHYLAMINO)-N-[6-(HYDROXYAMINO)-6-OXOHEXYL]-BENZAMIDE
Synonyms:4-(DIMETHYLAMINO)-N-[6-(HYDROXYAMINO)-6-OXOHEXYL]-BENZAMIDE;CAY10398;Benzamide, 4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-
CAS:193551-00-7
MF:C15H23N3O3
MW:293.36
EINECS:
Product Categories:Other enzyme inhibitors and activators;Other Enzyme Inhibitors.
Mol File:Mol File
4-(DIMETHYLAMINO)-N-[6-(HYDROXYAMINO)-6-OXOHEXYL]-BENZAMIDE Structure
4-(DIMETHYLAMINO)-N-[6-(HYDROXYAMINO)-6-OXOHEXYL]-BENZAMIDE Chemical Properties
storage temp. Store at -20°C
solubility DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:5): 300 μg/ml; DMSO: 14 mg/ml; Ethanol: 1 mg/ml
form A crystalline solid
Safety Information
MSDS Information
4-(DIMETHYLAMINO)-N-[6-(HYDROXYAMINO)-6-OXOHEXYL]-BENZAMIDE Usage And Synthesis
DescriptionCAY10398 is an inhibitor of histone deacetylase (HDAC1) with an IC50 value of 10 μM. Similar potency is observed with trapoxin A and B, whereas trichostatin A is more potent inhibitor of the enzyme. Trichostatin A also selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA. However, trichostatin A is much more expensive than CAY10398. CAY10398 thus represents a selective and cost-effective compound for the inhibition of HDAC.
UsesA histone deacetylase (HDAC1) inhibitor
References[1] STACY W. REMISZEWSKI. Inhibitors of Human Histone Deacetylase: Synthesis and Enzyme and Cellular Activity of Straight Chain Hydroxamates[J]. Journal of Medicinal Chemistry, 2002, 45 4: 753-757. DOI: 10.1021/jm015568c
[2] SYBILLE WITTICH. Effect of inhibitors of histone deacetylase on the induction of cell differentiation in murine and human erythroleukemia cell lines.[J]. Anti-Cancer Drugs, 2005, 16 6: 635-643. DOI: 10.1097/00001813-200507000-00008
[3] NANIKA COETZEE. Epigenetic inhibitors target multiple stages of Plasmodium falciparum parasites.[J]. ACS Applied Electronic Materials, 2020: 2355. DOI: 10.1038/s41598-020-59298-4
4-(DIMETHYLAMINO)-N-[6-(HYDROXYAMINO)-6-OXOHEXYL]-BENZAMIDE Preparation Products And Raw materials
Tag:4-(DIMETHYLAMINO)-N-[6-(HYDROXYAMINO)-6-OXOHEXYL]-BENZAMIDE(193551-00-7) Related Product Information
M344 BChE/HDAC6-IN-1 Benzamide, 4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-N-[2-oxo-2-[(phenylmethyl)amino]ethyl]- 4-(DIMETHYLAMINO)-N-[6-(HYDROXYAMINO)-6-OXOHEXYL]-BENZAMIDE N-[4-(2-oxopiperidin-1-yl)phenyl]benzamide Benzamide, 4-(dimethylamino)-N-propyl-